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Related Concept Videos

External Anatomy of the Kidney01:21

External Anatomy of the Kidney

744
The kidneys are a pair of bean-shaped organs in the human body that play a critical role in maintaining overall health. They filter out waste products from the blood, regulate blood pressure, maintain electrolyte balance, and stimulate the production of red blood cells.
The kidneys are located in the retroperitoneal space on either side of the vertebral column, protected posteriorly by the 11th and 12th ribs. The right kidney sits slightly lower than the left owing to the presence of the liver...
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Hormonal Regulation01:33

Hormonal Regulation

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The renin-aldosterone system is an endocrine system which guides the renal absorption of water and electrolytes, thus managing blood pressure and osmoregulation. Activation of the system begins in the kidneys with a small cluster of cells adjacent to the afferent and efferent blood vessels of the renal corpuscle. As the nephrons are filtering blood, juxtaglomerular cells monitor blood pressure. If they detect a decrease in pressure, they release the hormone renin into the bloodstream.
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Obesity01:24

Obesity

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The Body Mass Index (BMI) is a numerical value derived from a person's weight and height, used to categorize individuals into weight ranges. It is calculated using the formula: weight in kilograms divided by height in meters squared. Obesity is a health condition characterized by excessive accumulation of adipose tissue that poses health risks, often diagnosed with a BMI ≥ 30. This excess fat storage occurs when surplus dietary calories are converted into triglycerides and stored in...
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Kidney Structure01:45

Kidney Structure

68.8K
The kidneys are two large bean-shaped organs located in the upper abdomen. They filter the blood several times a day to remove toxins and rebalance water and electrolytes of the circulatory system via the renal veins. The kidneys receive blood directly from the heart via the renal arteries. These arteries enter the kidney at the hilum, the concave surface of the bean, where they branch and divide into smaller vessels and capillaries.
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Filtration and Urine Formation01:32

Filtration and Urine Formation

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The function of the kidneys is to filter, reabsorb, secrete, and excrete. Every day the kidneys filter nearly 180 liters of blood, initially removing water and solutes but ultimately returning nearly all filtrates into circulation with the help of osmoregulatory hormones. This process removes wastes and toxins but is also crucial to maintain water and electrolyte levels. Most of these functions are performed by the tiny but numerous nephrons contained within the kidneys.
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Related Experiment Video

Updated: Jun 4, 2025

Comparative Proteomic Analysis of Whole Kidney, Medulla, and Cortical Tubules in Diabetic Pathogenesis of Kidney Injury in Mice
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Comparative Proteomic Analysis of Whole Kidney, Medulla, and Cortical Tubules in Diabetic Pathogenesis of Kidney Injury in Mice

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Research Progress on Obesity-Associated Kidney Diseases.

Rui-Feng Yang1, Wen Wu2,3, Peng Zhang4

  • 1Department of Nephrology, The Sixth People's Hospital,Shanghai Jiaotong University School of Medicine,Shanghai 201306,China.

Zhongguo Yi Xue Ke Xue Yuan Xue Bao. Acta Academiae Medicinae Sinicae
|December 26, 2024
PubMed
Summary

Obesity-associated kidney disease (OAKD) arises from factors like inflammation and insulin resistance. Treatments include lifestyle changes, medication, surgery, and fecal transplants for better OAKD management.

Keywords:
obesityobesity-associated kidney diseasepathogenesistreatment strategy

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Last Updated: Jun 4, 2025

Comparative Proteomic Analysis of Whole Kidney, Medulla, and Cortical Tubules in Diabetic Pathogenesis of Kidney Injury in Mice
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Area of Science:

  • Nephrology
  • Metabolic Diseases
  • Microbiome Research

Background:

  • Obesity-associated kidney disease (OAKD) is a growing concern with complex underlying mechanisms.
  • Key factors include renin-angiotensin-aldosterone system overactivation, insulin resistance, chronic inflammation, lipid metabolism disorders, and gut dysbiosis.

Purpose of the Study:

  • To elucidate the multifaceted pathogenesis of OAKD.
  • To outline current and potential therapeutic strategies for OAKD.

Main Methods:

  • Review of existing literature on OAKD pathogenesis.
  • Analysis of current treatment modalities including lifestyle, pharmacotherapy, surgery, and transplantation.

Main Results:

  • OAKD pathogenesis is multifactorial, involving metabolic, inflammatory, and microbial pathways.
  • Current treatments are diverse, addressing different aspects of the disease.

Conclusions:

  • A comprehensive understanding of OAKD's pathogenesis is crucial for developing targeted prevention and treatment strategies.
  • Future research should focus on personalized and precise approaches to manage OAKD effectively.