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Canine and Feline Pemphigus Foliaceus-an Update on Pathogenesis and Treatment
Tyler J M Jordan1, Petra Bizikova2
1Department of Medicine and Epidemiology, School of Veterinary Medicine, University of California, Davis, One Shields Avenue, Davis, CA 95616, USA.
The Veterinary Clinics of North America. Small Animal Practice
|December 26, 2024
Summary
Pemphigus foliaceus (PF) is a common autoimmune skin disease in pets. This review covers its causes, symptoms, and current treatments, including immunosuppressive drugs.
Area of Science:
- Veterinary Dermatology
- Immunology
- Autoimmune Diseases
Background:
- Pemphigus foliaceus (PF) is a prevalent autoimmune skin condition affecting dogs and cats.
- Characterized by pustules, crusts, erosions, scales, and alopecia.
- Pathogenesis involves immune dysregulation and autoantibodies targeting keratinocyte cell surfaces.
Purpose of the Study:
- To review current knowledge on the pathogenesis of canine and feline PF.
- To summarize traditional and emerging therapeutic strategies for PF in dogs and cats.
Main Methods:
- Literature review of scientific articles and veterinary publications.
- Synthesis of information on PF pathophysiology, clinical signs, and treatment options.
Main Results:
- PF pathophysiology is incompletely understood but involves immune system dysfunction.
- Current management relies heavily on long-term immunosuppressive medications.
Conclusions:
- Further research is needed to fully elucidate PF pathogenesis.
- A comprehensive understanding of PF treatments, both established and novel, is crucial for effective pet care.
