Canine and Feline Pemphigus Foliaceus-an Update on Pathogenesis and Treatment

Pemphigus foliaceus (PF) is one of the most common autoimmune skin diseases of dogs and cats and is characterized by the development of pustules, crusts, erosions, scales, and alopecia. Albeit poorly understood, the pathophysiology of canine and feline PF appears to involve immune dysregulation and immunoglobulin G autoantibodies that are directed against the keratinocyte cell surface. At present, the management of canine and feline PF relies on the long-term to lifelong prescription of immunosuppressive medications. Current knowledge on the pathogenesis of canine and feline PF, as well as traditional and emerging therapies used to treat both diseases, will be reviewed herein.