Related Experiment Video For Clipped node
Updated: Jun 4, 2025
The Application of 1% Methylene Blue Dye As a Single Technique in Breast Cancer Sentinel Node Biopsy
Published on: June 1, 2019
Diagnostic accuracy of sentinel lymph node biopsy and wire localized clipped node biopsy after neoadjuvant
Xinguang Wang1, Qijun Zheng1, Yingjian He1
1Breast Center, Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education), Peking University Cancer Hospital & Institute, Beijing, 100142, China.
Purpose:
The optimal method for axillary staging in patients with initially node-positive breast cancer after NACT remains unclear.
Methods:
We conducted a prospective, single-center trial to investigate the diagnostic performance of sentinel lymph node biopsy (SLNB) combined with wire localized lymph node biopsy (WLNB) of the clip-marked node as an axillary staging technique in patients with node-positive breast cancer after neoadjuvant chemotherapy (NACT).
Results:
A total of 233 patients were enrolled, 208 of whom were included in the analysis. The IR of SLNB and WLNB alone were 63.0% and 70.7%, respectively. The identification rate (IR) of targeted axillary dissection (TAD) was 87.5%. The FNR of and NPV were 6.9% (95% confidence interval [CI]:2.0-11.8%) and 92.0% (95% CI 86.3-97.7%), respectively, for the TAD procedure, 17.1% (95% CI 8.2-25.6%) and 83.3% (95% CI:74.7-91.9%) for SLNB alone, and 6.7% (95% CI:1.5-12.0%) and 90.6% (95% CI:83.5-97.7%) for WLNB alone.
Conclusions:
The diagnostic performance of TAD using wire localization was similar to that of the procedure performed using radioactive seed localization. (Clinical Trial Registration: NCT03715686).
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