Efficient electrochemiluminescence sensor utilizing Zr-PyTCPPMOF for swift hydrogen sulfide detection.

Area of Science:

• Materials Science
• Analytical Chemistry
• Nanotechnology

Background:

• Hydrogen sulfide (H2S) is a crucial signaling molecule in biological systems and an environmental pollutant.
• Accurate and sensitive detection of H2S is vital for environmental monitoring and early disease diagnosis.
• Existing detection methods often lack the required sensitivity or specificity for trace H2S analysis.

Purpose of the Study:

• To develop an ultrahigh-sensitive electrochemiluminescence (ECL) sensor for hydrogen sulfide (H2S) detection.
• To design and synthesize a novel dual-ligand metal-organic framework (MOF) for enhanced H2S sensing capabilities.
• To evaluate the sensor's performance in terms of sensitivity, linear range, and applicability to real samples.

Main Methods:

• Synthesis of a spindle-shaped zirconium-based MOF (Zr-PyTCPPMOF) using tetrakis(4-carboxyphenyl) porphyrin (TCPP) and 1,3,6,8-tetrakis(4-carboxyphenyl) pyrene (TBAPy) as ligands.
• Fabrication of an ECL sensor utilizing the synthesized Zr-PyTCPPMOF.
• Characterization of the MOF's structure and H2S binding properties.
• Performance evaluation of the ECL sensor, including linear range, detection limit, and recovery in serum samples.

Main Results:

• Successful synthesis of the dual-ligand Zr-PyTCPPMOF with abundant nitrogen binding sites for sulfur.
• The ECL sensor demonstrated a wide linear relationship for H2S detection from 0.01 to 100 μM.
• Achieved an ultra-low detection limit of 1.18 nM (S/N = 3) for H2S.
• High recovery rates (96.6-106.2%) were observed when analyzing actual serum samples.

Conclusions:

• The novel dual-ligand MOF-based ECL sensor provides ultrahigh sensitivity for trace H2S detection.
• The sensor exhibits excellent performance, making it suitable for practical applications.
• This platform offers reliable technical support for early environmental monitoring and disease diagnosis.