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Effects of Age on the Bone-Conduction Amplitude-Modulated cVEMP Temporal Modulation Transfer Function
Raghav H Jha1, Erin G Piker2, Christopher G Clinard2
1School of Communication Sciences and Disorders, University of Memphis, Memphis, Tennessee, USA.
Ear and Hearing
|December 27, 2024
Summary
Aging significantly degrades amplitude-modulated cervical vestibular evoked myogenic potentials (AMcVEMPs), impacting vestibular function assessment. This study reveals age-related declines in AMcVEMP amplitude, SNR, and PC across modulation frequencies.
Area of Science:
- Neuroscience
- Vestibular System Research
- Audiology
Background:
- Cervical vestibular evoked myogenic potentials (cVEMPs) assess vestibular function via saccular stimulation.
- Amplitude-modulated cVEMPs (AMcVEMPs) offer detailed insights into vestibulo-collic reflexes.
- Age-related changes in AMcVEMPs remain largely uncharacterized.
Purpose of the Study:
- To investigate the impact of aging on AMcVEMPs.
- To analyze age-related effects on AMcVEMP amplitude, signal-to-noise ratio (SNR), and phase coherence (PC).
- To examine AMcVEMP responses across a wide range of modulation frequencies (MFs).
Main Methods:
- Included young (20-39), mid-age (40-59), and older (60-75) adults.
- Utilized amplitude-modulated tones (500 Hz carrier, 11-397 Hz MFs) as stimuli.
- Recorded AMcVEMPs from sternocleidomastoid muscles and analyzed using FFT with amplitude, SNR, and PC metrics.
Main Results:
- AMcVEMP waveforms showed periodicity matching stimulus MFs.
- Significant age-related decreases in AMcVEMP amplitude, SNR, and PC were observed.
- Young adults showed robust responses across a wider MF range compared to older adults, reducing the temporal modulation transfer function (TMTF).
Conclusions:
- Aging significantly impairs AMcVEMP responses, though not uniformly across measures or MFs.
- The TMTF of AMcVEMPs flattens and narrows with age.
- Findings improve understanding of age-related vestibular system changes and AMcVEMP's clinical potential.
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