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A Detailed Protocol for Perspiration Monitoring Using a Novel, Small, Wireless Device

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Composite Nanofiber Membrane-Based Microfluidic Fluorescence Sensors for Sweat Analysis.

Xuecui Mei^1,2, Lei Zhou¹, Liang Zhu^3,4

¹Yangtze Delta Region Institute (Huzhou), University of Electronic Science and Technology of China, Huzhou 313001, China.

Analytical Chemistry

|December 27, 2024

Summary

This study introduces a novel composite nanofiber membrane (CNMF) microfluidic chip for wearable sweat collection. The innovative design enhances comfort by preventing sweat accumulation, improving sensor reliability.

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Area of Science:

Biomedical Engineering
Materials Science
Analytical Chemistry

Background:

Wearable microfluidic chips are essential for sweat analysis but often suffer from sweat accumulation, impacting sensor performance and user comfort.
Existing materials like poly(dimethylsiloxane) (PDMS) and paper-based chips face challenges in managing sweat at the skin-sensor interface.

Purpose of the Study:

To develop a composite nanofiber membrane (CNMF)-based microfluidic chip for improved in situ sweat collection and analysis.
To address the issue of sweat accumulation in wearable sensors, enhancing both wearing comfort and sensing stability.

Main Methods:

Integration of a CNMF with directional water transport capability with patterned PDMS to create microfluidic chips.
Development of a CNMF-based microfluidic fluorescence sensor for multiplexed sweat analysis.
Utilization of a portable 3D-printed device for visual signal readout.

Main Results:

The CNMF-based microfluidic chip demonstrated directional sweat transport, effectively preventing accumulation at the skin-sensor interface.
The system facilitated a comfortable skin microenvironment by managing sweat transfer from hydrophobic to hydrophilic surfaces.
The microfluidic fluorescence sensor showed excellent reliability in collecting and analyzing multiple targets in human sweat.

Conclusions:

The proposed CNMF microfluidic chip offers a promising solution for comfortable and reliable wearable sweat sensing.
This work provides valuable insights for designing advanced microfluidic systems with enhanced user experience and analytical performance.