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The serotonergic psychedelic DOI impairs deviance detection in the auditory cortex.

Max Horrocks¹, Jennifer L Mohn¹, Santiago Jaramillo¹

¹Institute of NeuroscienceUniversity of Oregon, Eugene. Oregon, United States.

Journal of Neurophysiology

|December 27, 2024

Summary

The psychedelic compound DOI increases variability in auditory cortex neural responses and impairs the detection of unexpected sounds. This suggests psychedelics disrupt sensory processing by reducing sensitivity to novel auditory events.

Keywords:

auditory oddball perceptual distortions psychedelics top-down

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Area of Science:

Neuroscience
Psychopharmacology
Auditory Neuroscience

Background:

Psychedelics induce perceptual distortions, but neural mechanisms in the auditory system are unclear.
Serotonin 2A receptors are implicated in psychedelic effects.
Understanding auditory processing changes is key to understanding psychedelic states.

Purpose of the Study:

Investigate DOI's effects on auditory cortical neuron activity in mice.
Examine DOI's impact on sound-frequency tuning, response variability, and deviance detection.
Elucidate neural mechanisms of psychedelic-induced auditory alterations.

Main Methods:

Administered DOI (serotonin 2A agonist) to awake mice.
Recorded neural activity in the auditory cortex.
Analyzed frequency tuning, response variability, and deviance detection.

Main Results:

DOI did not consistently alter auditory neuron frequency selectivity.
DOI increased trial-by-trial neural response variability.
DOI diminished the neural distinction between standard and oddball sounds, reducing deviance detection.

Conclusions:

DOI dampens auditory cortex sensitivity to unexpected sounds.
Psychedelics disrupt sensory processing by altering neural response variability and deviance detection.
Findings offer insights into the neural basis of altered auditory perception during psychedelic states.