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Clinical Implications of Pan-Immune-inflammatory Values in Patients with Hypertrophic Cardiomyopathy

Levent Pay1, Ahmet Cagdas Yumurtas2, Seyda Dereli3

  • 1Istanbul Haseki Training and Research Hospital, Department of Cardiology, Istanbul, Turkey.

Medeniyet Medical Journal
|December 27, 2024
PubMed

Insights

The pan-immune inflammation value (PIV) may predict long-term mortality in hypertrophic cardiomyopathy (HCM) patients. Higher PIV levels indicate increased risk, suggesting PIV as a potential screening tool for adverse outcomes in HCM.

Area of Science:

  • Cardiology
  • Inflammation Biomarkers
  • Medical Prognostics

Background:

  • Hypertrophic cardiomyopathy (HCM) requires improved risk stratification for adverse outcomes.
  • Inflammation is linked to HCM severity, necessitating new prognostic markers.
  • The pan-immune inflammation value (PIV) is a novel inflammation marker.

Purpose of the Study:

  • To investigate the prognostic value of the pan-immune inflammation value (PIV) in a large cohort of HCM patients.
  • To determine the association between PIV levels and long-term mortality in HCM.
  • To explore PIV as a potential screening tool for identifying high-risk HCM patients.

Main Methods:

  • A cohort of 389 HCM patients was analyzed retrospectively (2004-2021).
  • Pan-immune inflammation value (PIV) calculated as (Neutrophil count × Platelet count × Monocyte count) / Lymphocyte count.
  • Patients were stratified into three PIV tertiles to evaluate long-term mortality risk.

Main Results:

  • Over a mean follow-up of 55.5 months, 47 (12.1%) patients died.
  • Long-term mortality increased across PIV tertiles (7 in tertile 1, 12 in tertile 2, 28 in tertile 3).
  • Multivariate analysis showed a 3.5-fold higher mortality risk in the highest PIV tertile compared to the lowest.

Conclusions:

  • Elevated pan-immune inflammation value (PIV) is associated with increased long-term mortality in HCM patients.
  • PIV demonstrates potential as a valuable screening tool for risk stratification in HCM.
  • Further research may validate PIV for clinical use in managing HCM patients.
Abstract

Keywords:
Hypertrophic cardiomyopathypan-immune-inflammation valueprognosissystemic inflammatory markers

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