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Related Concept Videos

Inflammatory Bowel Disease I: Ulcerative Colitis01:27

Inflammatory Bowel Disease I: Ulcerative Colitis

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Introduction
Inflammatory bowel disease, or IBD, encompasses a group of disorders characterized by chronic inflammation or ulceration of the gastrointestinal tract.
Risk Factors
The exact cause of IBD remains unclear, although it is believed to be due to a mix of genetic, environmental, microbial, and immune factors. Genetic factors are significant in determining susceptibility to IBD, with family history being a critical risk factor. Individuals with a first-degree relative who has IBD are at...
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Inflammatory Bowel Disease III: Diagnostic Studies and Management I-Nutritional Therapy01:30

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Various diagnostic tests are employed in the diagnostic process for Inflammatory Bowel Disease (IBD), particularly to differentiate between Crohn's disease and ulcerative colitis.
Diagnostic studies
A colonoscopy is the definitive screening test, distinguishing ulcerative colitis from other colon diseases with similar symptoms. During a colonoscopy test, inflamed mucosa with exudate ulcerations can be observed, and biopsies are taken to determine the histologic characteristics of the...
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Drugs for Treatment of Ulcerative Colitis in IBD01:29

Drugs for Treatment of Ulcerative Colitis in IBD

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Ulcerative colitis is a chronic inflammatory condition primarily affecting the colon and rectum. The primary drugs used in the treatment of ulcerative colitis are aminosalicylates. They exhibit anti-inflammatory and immunosuppressive properties. They modulate inflammatory mediators and inhibit the activity of nuclear factor κB (NF-κB). Aminosalicylates also reduce inflammation by inhibiting prostaglandin and leukotriene production and decreasing neutrophil chemotaxis and superoxide...
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Serum Laboratory Studies, Stool Test, Breath Test01:30

Serum Laboratory Studies, Stool Test, Breath Test

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Gastrointestinal (GI) diagnostic studies are pivotal in confirming, ruling out, diagnosing, or staging various diseases, including cancers. Following diagnosis, allocating time for discussions with the patient and providing informational resources is crucial. Diagnostic assessments of the GI tract often occur in outpatient settings like endoscopy suites or GI labs. Preparation for these tests may include dietary restrictions, fasting, liquid bowel preparations, laxatives, enemas, and the...
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Peptic Ulcer Disease III: Clinical Manifestations and Diagnostic Studies01:28

Peptic Ulcer Disease III: Clinical Manifestations and Diagnostic Studies

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Peptic ulcer disease (PUD) presents with diverse symptoms depending on the location and severity of the ulcer. Clinical manifestations of peptic ulcer include dull pain and a burning sensation in the mid-epigastric region.
Few clinical manifestations differentiate gastric ulcers from duodenal ulcers. Distinctions in the location, timing, and pain relief are crucial for healthcare providers in differentiating between gastric and duodenal ulcers during clinical assessments.
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Inflammatory Bowel Disease II: Crohn's Disease01:30

Inflammatory Bowel Disease II: Crohn's Disease

122
Introduction
Inflammatory bowel disease, commonly known as IBD, refers to a collection of disorders that lead to persistent inflammation of the gastrointestinal tract. The two types of IBD are ulcerative colitis, which impacts the colon, and Crohn's disease, which can involve any part of the gastrointestinal segment.
Crohn's disease
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Analyzing Beneficial Effects of Nutritional Supplements on Intestinal Epithelial Barrier Functions During Experimental Colitis
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The Serum Biomarkers in Ulcerative Colitis.

Semih Sezer1, Selim Demirci1, Melisa Irem Kara2

  • 1Health Sciences University Türkiye, Dr. Abdurrahman Yurtaslan Oncology Training and Research Hospital, Clinic of Gastroenterology, Ankara, Türkiye.

Medeniyet Medical Journal
|December 27, 2024
PubMed
Summary

The C-reactive protein to lymphocyte ratio (CLR) and C-reactive protein to albumin ratio (CAR) effectively detect ulcerative colitis (UC) activity. Neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR) showed limited diagnostic value for UC disease activity.

Keywords:
Ulcerative colitiscolonoscopyendoscopic activity indexinflammation markers

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Area of Science:

  • Gastroenterology
  • Clinical Diagnostics
  • Inflammatory Bowel Disease Research

Background:

  • Ulcerative colitis (UC) diagnosis and activity assessment often rely on invasive endoscopic procedures.
  • There is a need for cost-effective and easily applicable serum biomarkers to monitor UC disease activity.
  • Current biomarkers require further validation for their diagnostic utility in UC.

Purpose of the Study:

  • To evaluate the diagnostic effectiveness of serum biomarkers: neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), C-reactive protein (CRP) to albumin ratio (CAR), and CRP-to-lymphocyte ratio (CLR).
  • To compare the utility of these biomarkers against the endoscopic activity index (EAI) for determining UC disease activation.
  • To identify reliable, non-invasive markers for assessing UC activity.

Main Methods:

  • Retrospective review of blood tests from UC patients and controls, collected concurrently with colonoscopies.
  • Calculation of NLR, PLR, CAR, and CLR values.
  • Classification of patients into active UC (EAI ≥4), UC in remission (EAI <4), and control groups based on EAI scores.

Main Results:

  • The study included 66 active UC patients, 31 UC in remission, and 99 controls.
  • CLR and CAR values were significantly higher in active and remission UC patients compared to controls (p<0.001).
  • CLR and CAR demonstrated significant diagnostic value for active UC with optimal cut-off values of >1.75 and >0.11, respectively. PLR and NLR showed no significant difference between groups (p>0.05).

Conclusions:

  • CLR and CAR are sensitive and specific biomarkers for detecting UC activity.
  • NLR and PLR exhibit low diagnostic value for assessing UC disease activity.
  • CAR and CLR offer a promising, non-invasive approach for monitoring UC.