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Author Spotlight: Accurately Assessing Thyroid Hormone-Driven Motor Alterations in Mouse
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Thyroid Functions and Cognitive Decline in the Elderly.

Ayaz Muhammad1,2, Ijaz Ul Haq3, Mehr Ali Khan4

  • 1Internal Medicine, Mardan Medical Complex, Medical Teaching Institution, Mardan, PAK.

Cureus
|December 27, 2024
PubMed
Summary
This summary is machine-generated.

Thyroid hormone issues are linked to cognitive decline in older adults. Monitoring thyroid function is crucial for maintaining cognitive health in the elderly population.

Keywords:
cognitive declineelderlyfree t4mmsemocathyroid functiontsh

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Area of Science:

  • Gerontology
  • Endocrinology
  • Neuroscience

Background:

  • Cognitive health maintenance is influenced by thyroid hormones.
  • Thyroid hormone imbalances are increasingly recognized as potential contributors to age-related cognitive decline.

Purpose of the Study:

  • To investigate the association between thyroid hormone levels and cognitive decline in elderly individuals.
  • To explore the influence of age-related factors and comorbidities on this association.

Main Methods:

  • Prospective observational study over two years with 218 adults aged 60+.
  • Regular monitoring of thyroid-stimulating hormone (TSH), free thyroxine (T4), and free triiodothyronine (T3) levels.
  • Cognitive function assessed using Mini-Mental State Examination (MMSE) and Montreal Cognitive Assessment (MoCA).

Main Results:

  • Significant decrease in TSH and increase in free T4 levels observed over 24 months.
  • Marked decline in cognitive scores, including MMSE and MoCA, during the study period.
  • Multivariate regression identified factors associated with cognitive deterioration.

Conclusions:

  • A strong correlation exists between thyroid dysfunction and cognitive loss in the elderly.
  • Close monitoring of thyroid function is essential for preserving cognitive function in aging populations.