Related Experiment Video
Updated: Jul 26, 2026
07:25
In Vitro Methods for Comparing Target Binding and CDC Induction Between Therapeutic Antibodies: Applications in Biosimilarity Analysis
Published on: May 4, 2017
17.7K
Rituximab Safety Profile: A Seven-Year Retrospective Analysis From Southern India
Lakshmi Jayasree1, Princy L Palatty1, Laxmi Govindraj1
1Pharmacology, Amrita School of Medicine, Amrita Institute of Medical Sciences, Amrita Vishwa Vidyapeetham, Ernakulam, IND.
Cureus
|December 27, 2024
Summary
Rituximab use is generally safe, with most adverse drug reactions (ADRs) being mild and manageable. Vigilant monitoring is crucial for early detection of severe complications like lung disease, especially during initial infusions.
Area of Science:
- Pharmacovigilance
- Clinical Pharmacology
- Immunology
Background:
- Rituximab is an important therapeutic agent used in treating various conditions, including malignancies and autoimmune diseases.
- Understanding the safety profile of rituximab through real-world data is crucial for clinical decision-making.
Purpose of the Study:
- To analyze the pattern, severity, and outcomes of adverse drug reactions (ADRs) associated with rituximab use.
- To assess the safety profile of rituximab in a regional pharmacovigilance center in Kerala, India.
Main Methods:
- Retrospective analysis of rituximab-associated ADRs reported between 2017 and 2023.
- Assessment of ADR causality using WHO-UMC criteria and severity using the Modified Hartwig Siegel Scale.
Main Results:
- 74 patients reported ADRs, predominantly in females and those aged 51-60 years.
- Most ADRs (69 cases) occurred during the first dose, with infusion reactions being most common.
- While most ADRs were mild (67 cases) and patients recovered (72), two cases of rituximab-induced lung disease were associated with higher mortality.
Conclusions:
- Rituximab exhibits an acceptable safety profile with manageable ADRs and a high recovery rate.
- The potential for severe complications like rituximab-induced lung disease necessitates vigilant monitoring, particularly during early treatment phases.
- Findings emphasize the importance of standardized protocols for ADR mitigation to enhance rituximab's real-world safety.
Keywords:
adverse drug reactionscausality assessmentinfusion related reactionsmodified hartwig siegel scalepharmacovigilancerituximabrituximab-induced lung diseasesafety profilewho-umc criteriaMore Related Videos
![Dynamic Imaging of Chimeric Antigen Receptor T Cells with [18F]Tetrafluoroborate Positron Emission Tomography/Computed Tomography](/_next/image?url=https%3A%2F%2Fcloudfront.jove.com%2FCDNSource%2Fteasers%2F62334.jpg&w=3840&q=50)
09:34Dynamic Imaging of Chimeric Antigen Receptor T Cells with [18F]Tetrafluoroborate Positron Emission Tomography/Computed Tomography
Published on: February 17, 2022
3.2K
06:37Using Reference Reagents to Confirm Robustness of Cytokine Release Assays for the Prediction of Monoclonal Antibody Safety
Published on: September 15, 2023
498
Related Concept Videos
01:11Statistical Analysis: Overview
When we take repeated measurements on the same or replicated samples, we will observe inconsistencies in the magnitude. These inconsistencies are called errors. To categorize and characterize these results and their errors, the researcher can use statistical analysis to determine the quality of the measurements and/or suitability of the methods.
One of the most commonly used statistical quantifiers is the mean, which is the ratio between the sum of the numerical values of all results and the...
One of the most commonly used statistical quantifiers is the mean, which is the ratio between the sum of the numerical values of all results and the...
01:25Multimachine Stability
Multimachine stability analysis is crucial for understanding the dynamics and stability of power systems with multiple synchronous machines. The objective is to solve the swing equations for a network of M machines connected to an N-bus power system.
In analyzing the system, the nodal equations represent the relationship between bus voltages, machine voltages, and machine currents. The nodal equation is given by:
In analyzing the system, the nodal equations represent the relationship between bus voltages, machine voltages, and machine currents. The nodal equation is given by:
01:11Overview of Minitab
Minitab is a statistical software package designed for data analysis. With its origins in the 1970s and development at Pennsylvania State University, Minitab has grown significantly in its capabilities and applications. It plays a crucial role in quality management projects, especially in Six Sigma initiatives, by offering tools for process improvement and statistical analysis. Minitab's significance lies in its user-friendly interface, making complex statistical analysis accessible to users...
01:10Statgraphics
Statgraphics is a comprehensive statistical software suite designed for both basic and advanced data analysis. Originating in 1980 at Princeton University under Dr. Neil W. Polhemus, it was one of the pioneering tools for statistical computing on personal computers, with its public release in 1982 marking an early milestone in data science software. Over the years, it has evolved into a robust platform for data science, offering tools for regression analysis, ANOVA, multivariate statistics,...
01:25Interpreting Run Charts
Run charts, essentially line graphs plotted over time, serve as fundamental yet effective tools for process analysis. They chronicle data sequentially, facilitating the identification of trends, shifts, or cyclical movements. This graphical representation is instrumental in determining whether a process is stable or exhibits signs of potential instability indicative of special cause variation. In the healthcare domain, run charts depict infection rates over time, enabling hospitals to monitor...
01:21Manipulation and Analysis
GIS manipulation and analysis functions are vital for decision-making and planning. These activities range from data retrieval tasks, such as selecting information based on specific criteria, to advanced analytical techniques that address complex spatial problems.One critical GIS analysis method is overlaying, which combines multiple data layers to examine impacts. For example, overlaying a river-dammed lake boundary with road networks can identify affected infrastructure. Another common...