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Related Concept Videos

Genomics02:02

Genomics

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Genomics is the science of genomes: it is the study of all the genetic material of an organism. In humans, the genome consists of information carried in 23 pairs of chromosomes in the nucleus, as well as mitochondrial DNA. In genomics, both coding and non-coding DNA is sequenced and analyzed. Genomics allows a better understanding of all living things, their evolution, and their diversity. It has a myriad of uses: for example, to build phylogenetic trees, to improve productivity and...
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Next-generation Sequencing03:00

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The first human genome sequencing project cost $2.7 billion and was declared complete in 2003, after 15 years of international cooperation and collaboration between several research teams and funding agencies. Today, with the advent of next-generation sequencing technologies, the cost and time of sequencing a human genome have dropped over 100 fold.
Next-Generation Sequencing Methods
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Evolutionary Relationships through Genome Comparisons02:54

Evolutionary Relationships through Genome Comparisons

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Genome comparison is one of the excellent ways to interpret the evolutionary relationships between organisms. The basic principle of genome comparison is that if two species share a common feature, it is likely encoded by the DNA sequence conserved between both species. The advent of genome sequencing technologies in the late 20th century enabled scientists to understand the concept of conservation of domains between species and helped them to deduce evolutionary relationships across diverse...
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Genome-wide Association Studies-GWAS01:11

Genome-wide Association Studies-GWAS

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Genome-wide association studies or GWAS are used to identify whether common SNPs are associated with certain diseases. Suppose specific SNPs are more frequently observed in individuals with a particular disease than those without the disease. In that case, those SNPs are said to be associated with the disease. Chi-square analysis is performed to check the probability of the allele likely to be associated with the disease.
GWAS does not require the identification of the target gene involved in...
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What is Population Genetics?01:25

What is Population Genetics?

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A population is composed of members of the same species that simultaneously live and interact in the same area. When individuals in a population breed, they pass down their genes to their offspring. Many of these genes are polymorphic, meaning that they occur in multiple variants. Such variations of a gene are referred to as alleles. The collective set of all the alleles within a population is known as the gene pool.
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Genome Annotation and Assembly03:36

Genome Annotation and Assembly

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The genome refers to all of the genetic material in an organism. It can range from a few million base pairs in microbial cells to several billion base pairs in many eukaryotic organisms. Genome assembly refers to the process of taking the DNA sequencing data and putting it all back together in a correct order to create a close representation of the original genome. This is followed by the identification of functional elements on the newly assembled genome, a process called genome annotation.
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Microbial Communities in Nature and Laboratory - Interview
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Microbial Communities in Nature and Laboratory - Interview

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Behind the scenes with genomics researchers.

Renata Mont'Alverne1, Lori Bradford1, Cheryl Buckmaster2

  • 1School of Professional Development, College of Engineering, University of Saskatchewan, Saskatoon, SK, Canada.

Frontiers in Genetics
|December 27, 2024
PubMed
Summary

Genomics researchers face technical hurdles like incomplete databases and lack of reference values. They also grapple with public perception and publication practices that can slow scientific progress.

Keywords:
ethicslegal studiesoil sands process water (OPSW)philosophy of genomic researchsocial science

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Area of Science:

  • Environmental microbiology
  • Genomics
  • Bioremediation

Background:

  • Limited research exists on scientists' perceptions of their work in genomics, particularly concerning interdisciplinary collaboration.
  • Understanding these perspectives is crucial for advancing genomics applications in fields like bioremediation.

Purpose of the Study:

  • To explore the perceptions and positionalities of genomics researchers involved in bioremediation.
  • To identify challenges and broader reflections within the genomics discipline.

Main Methods:

  • Unstructured, open-ended interviews were conducted with researchers possessing diverse genomics expertise.
  • Thematic analysis was employed to analyze interview data, categorizing findings into microsystem and macrosystem levels.

Main Results:

  • Microsystem level: Identified technical barriers including incomplete databases and lack of established reference values, impacting project success and researcher stress.
  • Macrosystem level: Revealed concerns about public perception of genomics as genetic interventions and the publication system's bias towards positive results, hindering knowledge dissemination.

Conclusions:

  • Genomics scientists demonstrate self-awareness regarding how their beliefs influence research.
  • Addressing methodological gaps and fostering open publication of negative results are essential for scientific progress and societal acceptance of genomics.