LncRNA-Associated ceRNA Network Revealing the Potential Regulatory Roles of Ferroptosis and Immune Infiltration in Osteosarcoma as well as Construction of the Prognostic Model
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View abstract on PubMed
Summary
This summary is machine-generated.This study identifies ferroptosis-related long non-coding RNAs (lncRNAs) and constructs a prognostic model for osteosarcoma (OS). The findings offer new insights into OS pathological mechanisms and potential targeted therapy development.
Area Of Science
- Oncology
- Molecular Biology
- Bioinformatics
Background
- Osteosarcoma (OS) is a prevalent primary bone cancer.
- Long non-coding RNAs (lncRNAs) are increasingly recognized for their roles in ferroptosis and OS progression.
Purpose Of The Study
- Identify ferroptosis-related lncRNAs (frlncRNAs) in OS.
- Explore potential competing endogenous RNA (ceRNA) networks.
- Develop a novel prognostic model for OS.
Main Methods
- Data mining from TCGA, GEO, UCSC, and FerrDB databases.
- Construction of a lncRNA-miRNA-mRNA ceRNA network.
- Cox analysis for prognosis-related DEFRlncRNAs and prognostic model development.
- Immune cell infiltration analysis using CIBERSORT.
- GO and KEGG enrichment analyses.
Main Results
- Identified 247 differentially expressed FRlncRNAs (DEFRlncRNAs).
- Constructed a ceRNA network with 37 lncRNAs, 84 miRNAs, and 865 mRNAs.
- Developed a prognostic model using 8 prognosis-related DEFRlncRNAs, identifying metastasis and risk score as key factors.
- Revealed distinct immune cell infiltration patterns in OS, with elevated macrophages and T cells.
Conclusions
- Established a ferroptosis-related lncRNA-miRNA-mRNA regulatory network in OS.
- Developed a novel prognostic model for OS based on ferroptosis-related lncRNAs.
- Highlighted the association between the prognostic model and immune infiltration, offering insights for targeted therapy.
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