Related Experiment Video
Updated: Jun 4, 2025
10:46
A Method of Trigonometric Modelling of Seasonal Variation Demonstrated with Multiple Sclerosis Relapse Data
Published on: December 9, 2015
10.7K
Cognitive reserve predicts long-term cognitive trajectories in relapsing-remitting multiple sclerosis
Gianpaolo Maggi1, Manuela Altieri1, Mario Risi1
1Department of Advanced Medical and Surgical Sciences, University of Campania "Luigi Vanvitelli," Naples, Italy.
Multiple Sclerosis (Houndmills, Basingstoke, England)
|December 27, 2024
Summary
Cognitive reserve (CR) impacts cognitive trajectories in people with relapsing-remitting multiple sclerosis (pwRRMS). High CR is linked to cognitive improvement, while low CR predicts decline, highlighting the need for CR enhancement interventions.
Area of Science:
- Neuroscience
- Neurology
- Cognitive Science
Background:
- Cognitive reserve (CR) plays a role in maintaining cognition in relapsing-remitting multiple sclerosis (pwRRMS).
- Previous research on CR's long-term effects in pwRRMS is limited.
Purpose of the Study:
- To investigate the long-term cognitive trajectories of pwRRMS based on their CR.
- To identify predictors of cognitive changes over time in pwRRMS.
Main Methods:
- Neuropsychological evaluation of 78 pwRRMS at baseline and after a 6.5-year follow-up.
- Analysis of CR using the Vocabulary Knowledge Test (VOC).
- Statistical analysis including ANCOVA and regression, controlling for disability and depression.
Main Results:
- PwRRMS with high CR showed cognitive improvements, while those with low CR experienced cognitive decline.
- Vocabulary Knowledge Test (VOC) scores increased in the overall sample and predicted cognitive changes.
- Female sex was associated with VOC score increases.
Conclusions:
- Cognitive reserve, measured by VOC, can be enhanced and predicts long-term cognitive outcomes in pwRRMS.
- Identifying pwRRMS at risk due to low CR is crucial for implementing interventions.
- CR enhancement strategies may delay cognitive impairment in pwRRMS.
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