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Related Concept Videos

Factors Affecting Dissolution: Polymorphism, Amorphism and Pseudopolymorphism01:21

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231
Polymorphism refers to the existence of a drug substance in multiple crystalline forms, known as polymorphs. Recently, this term has been expanded to include solvates (forms containing a solvent), amorphous forms (non-crystalline forms), and desolvated solvates (forms from which the solvent has been removed).
Some polymorphic crystals possess lower aqueous solubility than their amorphous counterparts, leading to incomplete absorption. For instance, the oral suspension of Chloramphenicol, which...
231

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Polysaccharide-Based Drug Carriers-A Patent Analysis.

Snežana Ilić-Stojanović1, Fouad Damiri2, Adina Magdalena Musuc3

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This review highlights patents for natural polysaccharide drug delivery systems like fucoidan and pectin. These biomaterials offer safe, controlled release of pharmaceuticals, protected by patent filings.

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Area of Science:

  • Biomaterials Science
  • Drug Delivery Systems
  • Polymer Chemistry

Background:

  • Polysaccharide-based carriers are valued for drug delivery due to their non-toxicity, biocompatibility, and biodegradability.
  • These natural polymers effectively protect active pharmaceutical ingredients and enable controlled or modified release.
  • Patented innovations in this field represent a crucial, often undiscussed, aspect of the state-of-the-art.

Purpose of the Study:

  • To review and highlight patent documents related to specific natural polysaccharide drug delivery systems.
  • To analyze the innovative landscape of polysaccharide-based drug delivery as documented in patents.
  • To provide an overview of patent applications and granted patents in this domain.

Main Methods:

  • Systematic search of the Espacenet-European Patent Office database.
  • Utilized International Patent Classification (IPC) for targeted patent retrieval.
  • Analysis of patent information to identify trends and innovations in polysaccharide drug delivery.

Main Results:

  • Identified key patents focusing on fucoidan, pullulan, dextran, and pectin as drug delivery carriers.
  • Documented the evolution of innovation from early patent applications to recent granted patents.
  • Highlighted the unique information available in patent literature regarding drug delivery technologies.

Conclusions:

  • Natural polysaccharides like fucoidan, pullulan, dextran, and pectin are significant in patented drug delivery systems.
  • Patent analysis reveals a dynamic and evolving field of innovation in polysaccharide-based drug delivery.
  • Further exploration of patent literature is valuable for understanding the state-of-the-art in biomaterial drug delivery.