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Dendropanax morbifera Extracts for Cosmetic Applications: Systematic Review and Meta-Analysis.

Le Thi Nhu Ngoc¹, Ju-Young Moon², Young-Chul Lee³

¹Department of Nano Science and Technology Convergence, Gachon University, 1342 Seongnam-Daero, Sujeong-gu, Seongnam-si 13120, Gyeonggi-do, Republic of Korea.

Current Issues in Molecular Biology

|December 27, 2024

Summary

Dendropanax morbifera extracts (DMEs) show significant cosmetic benefits. This review confirms their effectiveness in reducing hyperpigmentation, inflammation, and bacterial growth, supporting their use in skincare products.

Keywords:

Dendorpanax morbifera anti-inflammatory antimicrobial hyperpigmentation meta-analysis

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Published on: August 23, 2024

Area of Science:

Dermatology and Cosmetology
Pharmacology
Natural Product Chemistry

Background:

The cosmetic industry seeks novel ingredients for skin health.
Dendropanax morbifera is a plant with traditional uses, but its cosmetic potential requires scientific validation.
Existing research on Dendropanax morbifera extracts (DMEs) for cosmetic applications is fragmented.

Purpose of the Study:

To systematically review and meta-analyze the cosmetic applications of Dendropanax morbifera extracts (DMEs).
To evaluate the efficacy of DMEs in improving skin appearance through their biocompatibility, whitening, anti-inflammatory, and antimicrobial properties.

Main Methods:

Systematic review and meta-analysis of 16 eligible individual studies.
Standardized Mean Difference (SMD) was used for comparative analysis between DME treatment and control groups.
Evaluation of DME effects on tyrosinase, melanin, interleukin markers (ILs), nitric oxide (NO) production, and bacterial growth.

Main Results:

DMEs demonstrated significant inhibition of tyrosinase (SMD = 6.85) and melanin production (SMD = 23.38), indicating potent anti-hyperpigmentation effects.
DMEs exhibited strong anti-inflammatory properties by suppressing ILs (SMD = 5.22) and reducing NO production (SMD = 6.92).
DMEs showed effective antimicrobial activity against bacteria implicated in skin disorders and high biocompatibility.

Conclusions:

Dendropanax morbifera extracts possess significant biocompatibility, anti-hyperpigmentation, anti-inflammatory, and antimicrobial properties.
These properties suggest DMEs are valuable for improving skin appearance and warrant further investigation.
The findings support the potential for clinical trials evaluating DMEs in cosmetic applications.