Dendropanax morbifera Extracts for Cosmetic Applications: Systematic Review and Meta-Analysis

We have conducted a systematic review and meta-analysis to evaluate the cosmetic applications of Dendropanax morbifera extracts (DMEs). A total of 261 articles were screened; however, after eliminating inappropriate studies, only 16 individual studies were eligible. The comparative standardized mean difference (SMD) between the DME treatment and control groups was used to evaluate the cosmetic properties of DME, including its biocompatibility, whitening effects, and anti-inflammatory and antimicrobial properties. DME treatment exhibited positive results in controlling hyperpigmentation, including effective inhibition of the production of tyrosinase and melanin, with SMDs of 6.85 [4.27, 9.44] and 23.38 [12.94, 33.82], respectively. Moreover, the results confirmed the anti-inflammatory properties in terms of suppressing the expression of interleukin markers (ILs) (SMD = 5.22 [3.12, 7.33]) and reducing NO production (SMD = 6.92 [2.89, 10.96]). DME treatment also effectively inhibited bacteria growth, which causes skin disorders. According to the results, DMEs are shown to be highly biocompatibility, with excellent anti-hyperpigmentation, anti-inflammatory, and antimicrobial properties that contribute significantly to improving skin appearance. The findings provide strong evidence for further research into the in vivo effects of DMEs and their potential cosmetic applications, which could lead to clinical trials in the future.