BDNF/Cyclin D1 Signaling System and Cognitive Performance After Perampanel and Lacosamide Treatment Singly or in Combination in an Experimental Model of Temporal Lobe Epilepsy
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View abstract on PubMed
Summary
This summary is machine-generated.Perampanel and lacosamide treatments improved cognitive function and reduced anxiety in an epilepsy model. Both drugs, individually or combined, enhanced brain-derived neurotrophic factor (BDNF) and reduced Cyclin D1 levels.
Area Of Science
- Neuroscience
- Pharmacology
- Epilepsy Research
Background
- Epilepsy is a prevalent neurological disorder affecting brain function.
- Comorbid anxiety and cognitive impairment are significant challenges in epilepsy management.
- Temporal lobe epilepsy models are crucial for studying disease mechanisms and therapeutic interventions.
Purpose Of The Study
- To evaluate the long-term effects of perampanel (PRM) and lacosamide (LCM) on anxiety, cognition, BDNF, and Cyclin D1 in a rat model of temporal lobe epilepsy.
- To compare the efficacy of high-dose single-drug treatments versus low-dose combination therapy.
- To investigate the neurobiological mechanisms underlying the therapeutic effects.
Main Methods
- Adult Wistar rats were subjected to lithium-pilocarpine-induced status epilepticus.
- Treatment groups included high-dose PRM, high-dose LCM, and a low-dose combination of PRM+LCM.
- Behavioral tests (elevated plus maze, Y-maze, object recognition) assessed anxiety and memory.
- Hippocampal expression of BDNF and Cyclin D1 was analyzed.
Main Results
- Both high-dose single treatments and the low-dose combination of PRM and LCM significantly improved cognitive impairment, including passive learning, memory, and spatial/recognition memory.
- Anxiety-like behaviors were ameliorated by the treatments.
- All treatment groups showed increased hippocampal BDNF expression and decreased Cyclin D1 levels.
- The combination therapy demonstrated comparable efficacy to single-drug treatments.
Conclusions
- Perampanel and lacosamide, administered singly or in combination, exhibit significant anxiolytic and cognitive-enhancing effects in an epilepsy model.
- These anticonvulsants may preserve neuronal survival and CNS homeostasis by modulating BDNF and Cyclin D1 pathways.
- The findings suggest potential therapeutic benefits for managing comorbid anxiety and cognitive deficits in epilepsy.
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