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Cerebrospinal Drain Infection by Candida auris: A Case Report and Review of the Literature
Asimenia Halioti1, Charikleia S Vrettou1, Eleftherios Neromyliotis2
1First Department of Critical Care Medicine, Evangelismos Hospital, Medical School, National and Kapodistrian University of Athens, 106 76 Athens, Greece.
Abstract:
Candida auris is notorious for its ability to spread within healthcare environments, particularly in intensive care units (ICUs), posing significant challenges for clinicians as treatment options become limited. This is especially concerning in the context of central nervous system (CNS)-invasive infections. While rare, its involvement in nosocomial brain ventriculitis presents substantial diagnostic and therapeutic challenges, with no established guidelines for managing CNS infections caused by Candida auris. This report presents a case of Candida auris ventriculitis in an ICU patient and offers a comprehensive and targeted literature review, emphasizing diagnostic approaches, treatment strategies, and the clinical complexities of managing this emerging pathogen in CNS infections.
Insights
Candida auris brain infections are rare but challenging. This case highlights the need for better diagnostic and treatment strategies for this emerging pathogen in intensive care units (ICUs).
Area of Science:
- Infectious Diseases
- Critical Care Medicine
- Neuroscience
Background:
- Candida auris is an emerging multidrug-resistant fungal pathogen causing outbreaks in healthcare settings.
- Central nervous system (CNS) infections by Candida auris are rare but associated with high mortality.
- Nosocomial ventriculitis due to Candida auris presents unique diagnostic and therapeutic challenges.
Purpose of the Study:
- To report a case of Candida auris ventriculitis in an intensive care unit (ICU) patient.
- To conduct a comprehensive literature review on CNS infections caused by Candida auris.
- To emphasize diagnostic and treatment strategies for managing Candida auris CNS infections.
Main Methods:
- Case report of a patient with Candida auris ventriculitis.
- Systematic literature review of PubMed, Scopus, and Web of Science databases.
- Analysis of diagnostic methods, antifungal therapies, and clinical outcomes.
Main Results:
- The case involved a critically ill patient with Candida auris ventriculitis requiring prolonged antifungal treatment.
- Literature review identified limited data on Candida auris CNS infections, highlighting diagnostic difficulties and treatment variability.
- High mortality rates and treatment failures were noted in reported cases.
Conclusions:
- Candida auris ventriculitis is a rare but severe complication in ICU patients.
- Early diagnosis and aggressive antifungal therapy are crucial for improving outcomes.
- Further research and established guidelines are needed for effective management of Candida auris CNS infections.
