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Metabolic Aging as an Increased Risk for Chronic Obstructive Pulmonary Disease
Claire J Guo1, Suneeta Godbole1, Wassim W Labaki2
1Department of Biostatistics and Informatics, Colorado School of Public Health, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA.
Chronic obstructive pulmonary disease (COPD) is linked to accelerated metabolic aging, sharing common metabolomic signatures with the natural aging process. This accelerated aging correlates with more severe COPD disease.
Area of Science:
- Metabolomics
- Aging research
- Pulmonary medicine
Background:
- Aging and chronic obstructive pulmonary disease (COPD) significantly alter the metabolome.
- The relationship between aging and COPD metabolomic signatures remains unclear.
- Investigating accelerated aging in relation to COPD is crucial.
Purpose of the Study:
- To determine if common metabolomic signatures exist between aging and COPD.
- To investigate the association between accelerated aging and COPD.
- To develop and validate a metabolomic age score.
Main Methods:
- Analyzed plasma metabolomics data from 5704 COPDGene and 2449 SPIROMICS subjects (1013 metabolites).
- Defined COPD based on post-bronchodilator spirometry (FEV1/FVC < 0.7).
- Developed and validated a metabolomic age score using elastic net regression.
Main Results:
- Metabolic age score strongly correlated with chronological age (r=0.8) in the validation cohort.
- COPD subjects with accelerated aging (>7 years) exhibited more severe disease.
- Shared metabolites between aging and COPD were significantly higher than expected (p < 0.001), particularly in amino acid and glutathione metabolism.
Conclusions:
- A common underlying mechanism likely connects aging and COPD.
- COPD is associated with an acceleration of metabolic aging.
- Metabolomic profiling offers insights into COPD pathogenesis and aging.
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