Surface-Functionalizing Strategies for Multiplexed Molecular Biosensing: Developments Powered by Advancements in...

Area of Science:

• Nanotechnology
• Biosensing
• Materials Science

Background:

• Multiplexed biosensing is vital for understanding biological mechanisms and advancing medical diagnostics.
• Biosensor development, particularly for multiplexing, relies heavily on nanotechnology advancements.
• Surface functionalization is key for immobilizing biological probes and capturing target biomolecules.

Purpose of the Study:

• To review current studies on multiplexed biosensors.
• To focus on the specific roles of nanomaterials in the design and functionalization of these biosensors.
• To provide guidance on selecting methods for novel nanotechnology applications in biosensor development.

Main Methods:

• Review of existing literature on multiplexed biosensors and nanomaterials.
• Analysis of surface functionalization strategies involving nanomaterials.
• Discussion of nanotechnology applications in biosensor design.

Main Results:

• Nanomaterials play a critical role in nano-coating, micro-nano 3D structures, and nanotag signal generation for multiplexed biosensors.
• Surface functionalization strategies utilizing nanomaterials significantly impact biosensor performance.
• Various nanomaterials can be used as objects of surface modification or as modifying agents.

Conclusions:

• Nanomaterials are indispensable for enhancing the capabilities of multiplexed biosensors.
• Strategic use of nanomaterials in surface functionalization is critical for optimizing biosensor performance.
• This review aims to accelerate the adoption of nanotechnologies in advanced biosensor development.