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Affinity-Enriched Plasma Proteomics for Biomarker Discovery in Abdominal Aortic Aneurysms
Nicolai Bjødstrup Palstrøm1,2, Kristian Boje Nielsen1,2, Amanda Jessica Campbell1,2
1Center for Clinical Proteomics, Odense University Hospital, 5000 Odense, Denmark.
Proteomes
|December 27, 2024
Summary
Researchers identified 10 key proteins in plasma that can help diagnose abdominal aortic aneurysm (AAA), a dangerous aortic condition. This proteomic discovery offers potential new biomarkers for early AAA detection.
Area of Science:
- Proteomics
- Biomarker Discovery
- Cardiovascular Disease Research
Background:
- Abdominal aortic aneurysm (AAA) is a serious condition involving aortic dilation.
- Currently, few reliable diagnostic biomarkers exist for AAA.
- Early detection is crucial for managing this life-threatening disease.
Purpose of the Study:
- To identify novel plasma proteomic biomarkers for abdominal aortic aneurysm.
- To analyze proteomic changes associated with AAA using mass spectrometry.
- To develop a predictive model for AAA diagnosis.
Main Methods:
- Mass spectrometry-based proteomics on plasma from 45 AAA patients and 45 controls.
- Affinity enrichment of plasma samples.
- Gene ontology analysis to interpret proteomic data.
- Recursive feature elimination and random forest classification to identify predictive biomarkers.
Main Results:
- Significant upregulation of proteins involved in inflammation, coagulation, and extracellular matrix in AAA patients.
- Downregulation of angiogenesis-related proteins in AAA patients.
- Identification of a 10-protein signature highly predictive of AAA (AUC = 0.93).
Conclusions:
- A 10-protein panel shows high potential as a diagnostic biomarker for abdominal aortic aneurysm.
- Proteomic analysis reveals key biological pathways altered in AAA.
- Further validation in larger cohorts is required to confirm diagnostic utility.
