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Preparation, Purification, and Characterization of Lanthanide Complexes for Use as Contrast Agents for Magnetic Resonance Imaging

Preparation, Purification, and Characterization of Lanthanide Complexes for Use as Contrast Agents for Magnetic Resonance Imaging

Published on: July 21, 2011

Zinc Sensing with a Pyridine-Based Lanthanide Contrast Agent: Structural Analysis in Aqueous Solution.

Harlei Martin¹, Adrien Uguen¹, Jean-François Morfin¹

¹Centre de Biophysique Moléculaire, CNRS UPR 4301, Université d'Orléans, Rue Charles Sadron, 45071, Orléans, Cedex 2, France.

Chemistry (Weinheim an Der Bergstrasse, Germany)

|December 27, 2024

Summary

Researchers developed a novel Gadolinium (Gd³⁺)-based MRI contrast agent for detecting zinc (Zn²⁺). This agent shows high selectivity and efficacy for zinc, with potential applications in biological imaging.

Keywords:

Gadolinium Magnetic Resonance Imaging Molecular Imaging Zinc responsive probe

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An Aptamer-based Sensor for Unchelated GadoliniumIII

An Aptamer-based Sensor for Unchelated GadoliniumIII

Published on: January 9, 2017

Area of Science:

Inorganic Chemistry
Medical Imaging
Biophysical Chemistry

Background:

Zinc (Zn²⁺) dysregulation is linked to various diseases.
Non-invasive imaging of zinc is crucial for diagnostics.
Magnetic Resonance Imaging (MRI) offers a non-invasive imaging modality.

Purpose of the Study:

To synthesize and characterize a novel Gadolinium (Gd³⁺)-based complex for Zn²⁺ sensing using MRI.
To investigate the sensing mechanism and selectivity of the Gd³⁺ complex for Zn²⁺.
To evaluate the potential of the complex for biological applications.

Main Methods:

Synthesis of a novel Gd³⁺-based complex.
Nuclear Magnetic Resonance (NMR) spectroscopy.
Luminescence and potentiometric studies.
Relaxivity measurements.
Density Functional Theory (DFT) calculations.

Main Results:

The novel Gd³⁺ complex exhibits unique behavior influenced by a short linker.
Zn²⁺ binding significantly enhances the complex's efficacy.
The complex demonstrates high selectivity for Zn²⁺ over other physiological cations.
A key mechanism involves an increase in water molecules coordinated to Gd³⁺ upon Zn²⁺ binding.
The complex maintains a strong response in the presence of Human Serum Albumin.

Conclusions:

A novel Gd³⁺-based MRI contrast agent for Zn²⁺ sensing has been successfully developed.
The complex's response mechanism is elucidated, highlighting increased water coordination.
The agent's selectivity and performance in biological matrices suggest significant potential for in vivo zinc imaging.