Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

¹H NMR: Complex Splitting01:13

¹H NMR: Complex Splitting

1.2K
A proton M that is coupled to a proton X results in doublet signals for M. However, NMR-active nuclei can be simultaneously coupled to more than one nonequivalent nucleus. When M is coupled to a second proton A, such as in styrene oxide, each peak in the doublet is split into another doublet.
Splitting diagrams or splitting tree diagrams are routinely used to depict such complex couplings. While drawing splitting diagrams, the splitting with the larger coupling constant is usually applied...
1.2K
Ligand Binding and Linkage00:49

Ligand Binding and Linkage

4.8K
Allosteric proteins have more than one ligand binding site; the binding of a ligand to any of these sites influences the binding of ligands to the other sites. When a protein is allosteric, its binding sites are called coupled or linked.  In the case of enzymes, the site that binds to the substrate is known as the active site and the other site is known as the regulatory site. When a ligand binds to the regulatory site, this leads to conformational changes in the protein that can influence...
4.8K
¹³C NMR: Distortionless Enhancement by Polarization Transfer (DEPT)01:20

¹³C NMR: Distortionless Enhancement by Polarization Transfer (DEPT)

1.0K
When proton-coupled carbon-13 spectra are simplified by a broadband proton decoupling technique, structural information about the coupled protons is lost. Distortionless enhancement by polarization transfer (DEPT) is a technique that provides information on the number of hydrogens attached to each carbon in a molecule. While the DEPT experiment utilizes complex pulse sequences, the pulse delay and flip angle are specifically manipulated. The resulting signals have different phases depending on...
1.0K
Complexation Equilibria: The Chelate Effect01:19

Complexation Equilibria: The Chelate Effect

438
In complexation reactions, metal atoms or cations interact with ligands to form donor-acceptor adducts called metal complexes. Ligands that bind through one donor site are monodentate, ligands with two donor sites are bidentate, and those with more than two donor sites are polydentate ligands. For example, ethylene diamine is a bidentate ligand that binds through two nitrogen donor atoms, forming a five-membered ring. EDTA is a polydentate ligand that binds through four oxygen and two nitrogen...
438
Resonance and Hybrid Structures02:16

Resonance and Hybrid Structures

16.5K
According to the theory of resonance, if two or more Lewis structures with the same arrangement of atoms can be written for a molecule, ion, or radical, the actual distribution of electrons is an average of that shown by the various Lewis structures.
Resonance Structures and Resonance Hybrids
The Lewis structure of a nitrite anion (NO2−) may actually be drawn in two different ways, distinguished by the locations of the N–O and N=O bonds.
16.5K
Regioselectivity of Electrophilic Additions to Alkenes: Markovnikov's Rule02:17

Regioselectivity of Electrophilic Additions to Alkenes: Markovnikov's Rule

13.9K
If a set of reactants can yield multiple constitutional isomers, but one of the isomers is obtained as the major product, the reaction is said to be regioselective. In such reactions, bond formation or breaking is favored at one reaction site over others.
The hydrohalogenation of an unsymmetrical alkene can yield two haloalkane products, depending on which vinylic carbon takes up the halogen. However, one product usually predominates, where hydrogen adds to the vinylic carbon bearing the...
13.9K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Amino-Acid-Derived Androgen Receptor Modulators.

ACS medicinal chemistry letters·2026
Same author

Stenhouse Zwitterion Photoswitches as Hydrogen-Bond Acceptors.

Journal of the American Chemical Society·2026
Same author

Sulfonyl-tuned amino DASAs for targeted photophysical and photoswitching control.

Chemical science·2025
Same author

Iron-Catalyzed Cross-Electrophile Coupling.

Synlett : accounts and rapid communications in synthetic organic chemistry·2025
Same author

C(sp<sup>3</sup>)-heteroatom bond formation by iron-catalyzed soft couplings.

Communications chemistry·2025
Same author

β-Selective 2-Deoxy- and 2,6-Dideoxyglucosylations Catalyzed by Bis-Thioureas.

Journal of the American Chemical Society·2024

Related Experiment Video

Updated: Jun 4, 2025

Biochemical and Structural Characterization of the Carbohydrate Transport Substrate-binding-protein SP0092
08:53

Biochemical and Structural Characterization of the Carbohydrate Transport Substrate-binding-protein SP0092

Published on: October 2, 2017

29.8K

Compartmentalizing Donor-Acceptor Stenhouse Adducts for Structure-Property Relationship Analysis.

Cesar A Reyes1, Alexander Karr1, Chloe A Ramsperger1

  • 1Department of Chemistry, Loker Hydrocarbon Research Institute, University of Southern California, Los Angeles, California 90089, United States.

Journal of the American Chemical Society
|December 27, 2024
PubMed
Summary

Molecular photoswitches called donor-acceptor Stenhouse adducts (DASAs) can be tuned for smart materials and therapeutics. Their modular design allows modification for optimized light-responsive properties.

More Related Videos

Atomic Scale Structural Studies of Macromolecular Assemblies by Solid-state Nuclear Magnetic Resonance Spectroscopy
14:55

Atomic Scale Structural Studies of Macromolecular Assemblies by Solid-state Nuclear Magnetic Resonance Spectroscopy

Published on: September 17, 2017

15.4K
Analyzing Protein Dynamics Using Hydrogen Exchange Mass Spectrometry
11:37

Analyzing Protein Dynamics Using Hydrogen Exchange Mass Spectrometry

Published on: November 29, 2013

18.4K

Related Experiment Videos

Last Updated: Jun 4, 2025

Biochemical and Structural Characterization of the Carbohydrate Transport Substrate-binding-protein SP0092
08:53

Biochemical and Structural Characterization of the Carbohydrate Transport Substrate-binding-protein SP0092

Published on: October 2, 2017

29.8K
Atomic Scale Structural Studies of Macromolecular Assemblies by Solid-state Nuclear Magnetic Resonance Spectroscopy
14:55

Atomic Scale Structural Studies of Macromolecular Assemblies by Solid-state Nuclear Magnetic Resonance Spectroscopy

Published on: September 17, 2017

15.4K
Analyzing Protein Dynamics Using Hydrogen Exchange Mass Spectrometry
11:37

Analyzing Protein Dynamics Using Hydrogen Exchange Mass Spectrometry

Published on: November 29, 2013

18.4K

Area of Science:

  • Molecular photochemistry
  • Materials science
  • Organic electronics

Background:

  • Photoswitches are crucial for smart materials and therapeutics, requiring benign stimuli like low-energy light.
  • Donor-acceptor Stenhouse adducts (DASAs) are a class of molecular photoswitches responsive to visible and near-infrared light.

Purpose of the Study:

  • To provide a perspective on the electronic and steric contributions influencing DASA photophysical properties.
  • To highlight opportunities for expanding DASA architecture and photophysical capabilities through synthetic strategies.

Main Methods:

  • Focus on electronic and steric effects within DASA molecular compartments (donor, acceptor, triene, backbone heteroatom).
  • Analysis of how these modifications impact the isomerization energetic landscape and photophysical properties.
  • Review of current synthetic methodologies and their limitations.

Main Results:

  • DASAs offer modularity for tuning optical and photoswitching properties by modifying specific molecular compartments.
  • Electronic and steric factors significantly influence the photophysical behavior by altering the energy landscape of isomerization.
  • Current synthetic strategies present limitations but also opportunities for novel DASA designs.

Conclusions:

  • Tailoring DASA molecular architecture provides a pathway to engineer advanced photoswitching materials.
  • Understanding structure-property relationships is key to expanding the applications of DASAs in light-responsive technologies.
  • Further synthetic innovation is needed to unlock the full potential of DASA-based photoswitches.