Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Positron Emission Tomography01:29

Positron Emission Tomography

4.0K
Positron emission tomography (PET) is a medical imaging technique involving radiopharmaceuticals — substances that emit short-lived radiation. Although the first PET scanner was introduced in 1961, it took 15 more years before radiopharmaceuticals were combined with the technique and revolutionized its potential.
One of the main requirements of a PET scan is a positron-emitting radioisotope, which is produced in a cyclotron and then attached to a substance used by the part of the body...
4.0K
Imaging Studies II: Positron Emission Tomography and Scintigraphy01:25

Imaging Studies II: Positron Emission Tomography and Scintigraphy

81
Positron Emission Tomography (PET) is a medical imaging technique that provides crucial insights into the body's physiological functions at a molecular level. It is an indispensable resource for diagnosing, staging, and monitoring various illnesses, notably cancer, neurological disorders, and cardiovascular conditions.
Fundamental Principles of PET
81
Electron Microscope Tomography and Single-particle Reconstruction01:07

Electron Microscope Tomography and Single-particle Reconstruction

2.4K
Transmission electron microscopy (TEM) can be used to determine the 3D structure of biological samples with the help of techniques such as electron microscope tomography and single-particle reconstruction. While single-particle reconstruction can examine macromolecules and macromolecular complexes in vitro conditions only, tomography permits the study of cell components or small cells in vivo.
Electron Tomography
Electron tomography can be performed either in TEM or STEM (scanning transmission...
2.4K
Computed Tomography01:10

Computed Tomography

4.2K
Tomography refers to imaging by sections. Computed tomography (CT) is a non-invasive imaging technique that uses computers to analyze several cross-sectional X-rays to reveal minute details about structures in the body.
The technique was invented in the 1970s and is based on the principle that as X-rays pass through the body, they are absorbed or reflected at different levels. In the technique, a patient lies on a motorized platform while a computerized axial tomography (CAT) scanner rotates...
4.2K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Improved Edge Pixel Resolution in Modular PET Detectors with Partly Segmented Light Guides.

Sensors (Basel, Switzerland)·2025
Same author

Encapsulation of lysozyme within graphene sandwich reduces its thermal denaturation during SERS-analysis.

International journal of biological macromolecules·2025
Same author

Effect of High Zn Concentration on the Structural, Electrical, and Magnetic Properties of Zn-Doped Yttrium Iron Garnet Nanoparticles.

ACS omega·2025
Same author

Mechanical Stress-Induced Defects in Thick a-PbO Layers.

Materials (Basel, Switzerland)·2025
Same author

Transition to GPU-based reconstruction for clinical organ-targeted PET scanner.

Physics in medicine and biology·2025
Same author

Corrigendum: Case report: Possible role of low-dose PEM for avoiding unneeded procedures associated with false-positive or equivocal breast MRI results.

Frontiers in oncology·2024

Related Experiment Video

Updated: Jun 4, 2025

A Whole Body Dosimetry Protocol for Peptide-Receptor Radionuclide Therapy PRRT: 2D Planar Image and Hybrid 2D+3D SPECT/CT Image Methods
09:49

A Whole Body Dosimetry Protocol for Peptide-Receptor Radionuclide Therapy PRRT: 2D Planar Image and Hybrid 2D+3D SPECT/CT Image Methods

Published on: April 24, 2020

9.8K

Multi-angle acquisition and 3D composite reconstruction for organ-targeted PET using planar detectors.

Anirudh Shahi1, Harutyun Poladyan1, Edward Anashkin2

  • 1Department of Physics, Lakehead University, Thunder Bay, Ontario, Canada.

Medical Physics
|December 27, 2024
PubMed
Summary

This study introduces a multi-angle acquisition method to enhance organ-targeted PET imaging. The new technique significantly improves image quality by reducing smearing and increasing resolution for better diagnostic accuracy.

Keywords:
PETbrain PETbreast PETorgan‐targetedplanar detectors

More Related Videos

A Basic Positron Emission Tomography System Constructed to Locate a Radioactive Source in a Bi-dimensional Space
14:19

A Basic Positron Emission Tomography System Constructed to Locate a Radioactive Source in a Bi-dimensional Space

Published on: February 1, 2016

8.5K
Radiosynthesis, Quality Control, and Small Animal Positron Emission Tomography Imaging of 68Ga-Labelled Nano Molecules
09:55

Radiosynthesis, Quality Control, and Small Animal Positron Emission Tomography Imaging of 68Ga-Labelled Nano Molecules

Published on: October 4, 2024

304

Related Experiment Videos

Last Updated: Jun 4, 2025

A Whole Body Dosimetry Protocol for Peptide-Receptor Radionuclide Therapy PRRT: 2D Planar Image and Hybrid 2D+3D SPECT/CT Image Methods
09:49

A Whole Body Dosimetry Protocol for Peptide-Receptor Radionuclide Therapy PRRT: 2D Planar Image and Hybrid 2D+3D SPECT/CT Image Methods

Published on: April 24, 2020

9.8K
A Basic Positron Emission Tomography System Constructed to Locate a Radioactive Source in a Bi-dimensional Space
14:19

A Basic Positron Emission Tomography System Constructed to Locate a Radioactive Source in a Bi-dimensional Space

Published on: February 1, 2016

8.5K
Radiosynthesis, Quality Control, and Small Animal Positron Emission Tomography Imaging of 68Ga-Labelled Nano Molecules
09:55

Radiosynthesis, Quality Control, and Small Animal Positron Emission Tomography Imaging of 68Ga-Labelled Nano Molecules

Published on: October 4, 2024

304

Area of Science:

  • Medical Imaging
  • Nuclear Medicine
  • Radiological Physics

Background:

  • Organ-targeted PET systems offer advantages over conventional PET/CT, including adjustable axial field-of-view (AFOV) and improved signal collection.
  • Planar detector PET technology, while enabling quasi-3D reconstruction, faces limitations in axial spatial resolution and recovery coefficients (RCs).

Purpose of the Study:

  • To evaluate a multi-angle image acquisition strategy combined with composite 3D reconstruction for organ-targeted PET.
  • To improve axial spatial resolution and overcome intrinsic limitations of planar PET detectors.

Main Methods:

  • The Radialis organ-targeted PET camera was used for experimental and simulated imaging.
  • Acquisition and analysis involved custom phantoms, NEMA NU4-2008 IQ phantom, and a digital brain phantom.
  • Image quality metrics, including line profiles, uniformity, RCs, and axial smearing, were compared between multi-angle and single-angle acquisitions.

Main Results:

  • Multi-angle acquisition significantly reduced image smearing and improved uniformity (from ~10% to ~2.7%).
  • Recovery coefficients (RCs) were enhanced, and hot spheres appeared more symmetrical in composite images.
  • Simulations confirmed minimal axial smearing with a four-angle scan compared to a two-angle scan.

Conclusions:

  • The multi-angle acquisition method effectively transforms planar PET detectors into a true tomographic system, enhancing image quality.
  • This approach preserves the versatility of planar detector technology for organ-targeted imaging.
  • Future work will optimize protocols, detector spacing, angles, and incorporate advanced reconstruction techniques like TOF and PSF modeling.