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Optimizing Ewing Sarcoma and Osteosarcoma Biopsy Acquisition: A Children's Oncology Group Bone Tumor Committee
Matthew S Dietz1, Alyaa Al-Ibraheemi2, Jessica L Davis3
1University of Utah and Primary Children's Hospital, Salt Lake City, UT.
Journal of the National Comprehensive Cancer Network : JNCCN
|December 27, 2024
Summary
Image-guided core needle biopsies are increasingly used for bone sarcoma diagnosis, offering less invasive procedures. However, inconsistent tissue quality and quantity limit research, necessitating standardized biopsy practices for better patient outcomes.
Area of Science:
- Oncology
- Surgical Pathology
- Biomedical Research
Background:
- Diagnostic biopsy techniques for primary bone sarcomas have evolved over 20 years.
- Image-guided core needle biopsies are replacing open/incisional biopsies for Ewing sarcoma and osteosarcoma.
- While less invasive, core needle biopsies present challenges in tissue quantity and quality, impacting downstream analyses.
Purpose of the Study:
- To address the need for quality tumor specimens for molecular and clinical research in bone sarcomas.
- To outline current and future tissue requirements for optimal clinical care and research access.
- To provide guidance on biopsy practices to meet the evolving needs of patients with Ewing sarcoma and osteosarcoma.
Main Methods:
- A multidisciplinary expert group convened by the Children's Oncology Group Bone Tumor Committee.
- Review of current trends and limitations in diagnostic biopsy sample collection for bone sarcomas.
- Development of recommendations for harmonizing tissue collection and processing practices.
Main Results:
- Open/incisional biopsies were historically predominant but image-guided core needle biopsies are now more frequent.
- Variability in tissue yield and quality from core needle biopsies can limit molecular studies and research.
- Limited tissue availability hinders understanding of treatment resistance in advanced Ewing sarcoma and osteosarcoma.
Conclusions:
- Standardizing diagnostic biopsy practices is crucial for improving care for pediatric and young adult bone sarcoma patients.
- Harmonized tissue procurement and processing are essential for advancing research and identifying high-risk patient subsets.
- Improved biopsy strategies will facilitate discovery and enhance treatment outcomes for Ewing sarcoma and osteosarcoma.
