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Eighty-Nine Cases of Primary Prostatic Signet Ring Cell Carcinoma-Systematic Review
Madison Boot1, Kenneth Keen Yip Chew2, Jack Archer2
1Department of Urology, Wagga Wagga Base Hospital, Wagga Wagga, New South Wales, Australia.
Clinical Genitourinary Cancer
|December 27, 2024
Summary
Primary prostatic signet ring cell carcinoma is a rare, aggressive prostate cancer. This review of 89 cases shows a poor prognosis, with a 3-year survival rate of 17%, highlighting the need for more research.
Area of Science:
- Oncology
- Urology
- Pathology
Background:
- Signet ring cell adenocarcinoma is a rare subtype of mucinous adenocarcinoma.
- Prostatic signet ring cell carcinoma accounts for 0.02% of prostate cancer cases.
- It is an aggressive malignancy with limited existing literature.
Purpose of the Study:
- To summarize existing literature on primary prostatic signet ring cell carcinoma.
- To assess patient demographics, clinical presentations, investigations, treatments, and survival outcomes.
- To provide insights for future clinical management strategies.
Main Methods:
- Systematic review of 46 articles.
- Inclusion of 89 individual cases of primary prostatic signet ring cell carcinoma.
- Descriptive statistical analysis of extracted data.
Main Results:
- Average patient age was 68.5 years; most cases were in Caucasian individuals.
- Lower urinary tract symptoms were the most common presentation; elevated PSA was frequent.
- One-third of patients had metastatic disease at diagnosis; 3-year survival rate was approximately 17%.
Conclusions:
- Primary prostatic signet ring cell carcinoma is rare, aggressive, and has a poor prognosis.
- Limited literature necessitates further research into this condition.
- Findings enhance understanding and may guide future clinical management.
