Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Brain Imaging01:14

Brain Imaging

1.0K
Brain imaging technologies provide critical insights into both the structure and function of the human brain, enabling medical professionals and researchers to diagnose, study, and treat neurological disorders or psychiatric disorders more effectively.
These technologies include computerized axial tomography (CAT or CT scans), positron-emission tomography (PET scans),  magnetic resonance imaging (MRI),  functional magnetic resonance imaging (fMRI), and Transcranial Magnetic...
1.0K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Prediction of carbon dioxide solubility in sugar-water-alcohol solutions at high pressure for application to sparkling drinks.

Scientific reports·2026
Same author

Spatial scale of indentation explains shift in ratio between spinal cord gray and white matter stiffness.

Scientific reports·2026
Same author

Homing pigeon navigation relies on superparamagnetic macrophages under overcast conditions.

Science (New York, N.Y.)·2026
Same author

Machine Learning for Targeted Nano Medicine in Parkinson's Disease: A Data-Driven Approach for Diagnosis and Treatment.

Current topics in medicinal chemistry·2026
Same author

A hybrid approach for citrus disease detection using convolutional neural networks and fuzzy inference systems for enhanced accuracy and interpretability.

Scientific reports·2026
Same author

Permissive and instructive <i>Hox</i> codes govern limb positioning.

eLife·2026

Related Experiment Video

Updated: May 4, 2026

Induction of Experimental Autoimmune Encephalomyelitis in Mice and Evaluation of the Disease-dependent Distribution of Immune Cells in Various Tissues
08:47

Induction of Experimental Autoimmune Encephalomyelitis in Mice and Evaluation of the Disease-dependent Distribution of Immune Cells in Various Tissues

Published on: May 8, 2016

23.6K

MRI-based morphometric structural changes correlate with histopathology in experimental autoimmune encephalomyelitis.

Anna Lowinski1, Andreas Dabringhaus2, Matthias Kraemer3

  • 1Institute of Neuroanatomy, Faculty of Medicine, University of Bonn and University Hospital Bonn, Nussallee 10, 53115 Bonn, Germany.

Journal of the Neurological Sciences
|December 27, 2024
PubMed
Summary

Ex vivo MRI effectively detects spinal cord white matter atrophy in experimental autoimmune encephalomyelitis (EAE), a multiple sclerosis model. This atrophy strongly correlates with disease severity and neurohistopathology findings.

Keywords:
Experimental autoimmune encephalomyelitisMagnetic resonance imagingMultiple sclerosisT1T2T2*Voxel-guided morphometry

More Related Videos

Comprehensive Autopsy Program for Individuals with Multiple Sclerosis
09:41

Comprehensive Autopsy Program for Individuals with Multiple Sclerosis

Published on: July 19, 2019

11.4K
Author Spotlight: Unveiling the Pathway Linking Obesity to Autoimmune Inflammation in Multiple Sclerosis
08:17

Author Spotlight: Unveiling the Pathway Linking Obesity to Autoimmune Inflammation in Multiple Sclerosis

Published on: February 23, 2024

4.0K

Related Experiment Videos

Last Updated: May 4, 2026

Induction of Experimental Autoimmune Encephalomyelitis in Mice and Evaluation of the Disease-dependent Distribution of Immune Cells in Various Tissues
08:47

Induction of Experimental Autoimmune Encephalomyelitis in Mice and Evaluation of the Disease-dependent Distribution of Immune Cells in Various Tissues

Published on: May 8, 2016

23.6K
Comprehensive Autopsy Program for Individuals with Multiple Sclerosis
09:41

Comprehensive Autopsy Program for Individuals with Multiple Sclerosis

Published on: July 19, 2019

11.4K
Author Spotlight: Unveiling the Pathway Linking Obesity to Autoimmune Inflammation in Multiple Sclerosis
08:17

Author Spotlight: Unveiling the Pathway Linking Obesity to Autoimmune Inflammation in Multiple Sclerosis

Published on: February 23, 2024

4.0K

Area of Science:

  • Neuroscience
  • Medical Imaging
  • Immunology

Background:

  • Multiple sclerosis (MS) progression is evaluated using MRI and neurohistopathology.
  • Experimental autoimmune encephalomyelitis (EAE) serves as a key animal model for MS research.

Purpose of the Study:

  • To correlate clinical EAE severity with MRI and histopathological parameters.
  • To evaluate ex vivo MRI as a tool for assessing white matter atrophy in EAE.

Main Methods:

  • 11 female C57BL/6J mice were immunized with myelin oligodendrocyte glycoprotein (MOG) to induce EAE; 9 served as controls.
  • Longitudinal in vivo MRI was performed over 13 weeks, followed by ex vivo MRI (T1, T2*, DTI) of the spinal cord.
  • Histopathology included staining for immune cell infiltration, demyelination, astrogliosis, and axonal damage.

Main Results:

  • In vivo MRI showed no significant volume differences between EAE and control groups.
  • Ex vivo MRI revealed generalized spinal cord atrophy in EAE mice, particularly in the anterolateral tract.
  • A strong correlation was found between EAE score, white matter atrophy on ex vivo MRI, and histopathological damage.

Conclusions:

  • Ex vivo MRI is a valuable method for quantifying white matter atrophy in the EAE model.
  • The observed atrophy is directly linked to EAE severity and spinal cord histopathology.
  • This study highlights the utility of ex vivo MRI in understanding MS pathology.