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N6-methyladenosine (m6A) modification: Emerging regulators in plant-virus interactions

Yanjun Li1, Jianping Chen1, Zongtao Sun1

  • 1State Key Laboratory for Managing Biotic and Chemical Threats to the Quality and Safety of Agro-products, Key Laboratory of Biotechnology in Plant Protection of MARA, Key Laboratory of Green Plant Protection of Zhejiang Province, Institute of Plant Virology, Ningbo University, Ningbo, 315211, China.

Virology
|December 27, 2024
PubMed

Insights

N6-methyladenosine (m6A) regulates plant-virus interactions. This review summarizes m6A

Area of Science:

  • Epigenetics
  • Plant Virology
  • Molecular Biology

Background:

  • N6-methyladenosine (m6A) is a prevalent, reversible RNA modification influencing RNA fate and function.
  • m6A involves methyltransferases (writers), demethylases (erasers), and m6A-binding proteins (readers).
  • m6A's role in animal virus-host interactions is established, but its role in plant viruses is emerging.

Purpose of the Study:

  • To review current knowledge on the functions and molecular mechanisms of m6A in plant-virus interactions.
  • To highlight the early stage of research in this field.

Main Methods:

  • Review of existing literature on m6A modifications in plant-virology.
  • Summary of findings from recent sequencing technologies enabling genome-wide m6A mapping.

Main Results:

  • m6A modification plays a significant role in regulating plant-virus interactions.
  • Understanding these interactions is crucial for deciphering viral infection mechanisms in plants.

Conclusions:

  • Further research into m6A in plant-virus interactions is needed.
  • Insights gained may lead to novel antiviral strategies for controlling plant viral diseases.
Keywords:
N6-methyladenosine (m6A)Plant virusPlant-virus interactionsRNA methylationViral RNAs

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