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Elevated Plasma Soluble (Pro)renin receptor as a potential indicator for heart failure.
Jianhua Xiong1, Huiru Yang2, Xiaoli Yi2
1Translational Medicine Centre, Jiangxi University of Chinese Medicine, Nanchang 330004, China; Department of Cardiology, Affiliated Hospital of Jiangxi University of Chinese Medicine, Nanchang 330006, China.
Peptides
|December 27, 2024
Summary
Plasma levels of soluble (pro)renin receptor (sPRR) are elevated in heart failure (HF) patients. This finding suggests sPRR may serve as a valuable indicator for diagnosing and assessing HF severity.
Area of Science:
- Cardiology and Nephrology
- Biomarker Discovery
- Renin-Angiotensin System Research
Background:
- Soluble (pro)renin receptor (sPRR) levels are linked to various diseases, including kidney disease, hypertension, and heart failure (HF).
- Previous research focused on HF with reduced ejection fraction, leaving a gap in understanding sPRR in HF with preserved ejection fraction (HFpEF).
- The diagnostic and prognostic value of sPRR in HF, particularly HFpEF, requires further investigation.
Purpose of the Study:
- To clarify the role of plasma sPRR levels in patients with heart failure (HF) through meta-analysis.
- To investigate the relationship between plasma sPRR levels and HF, with a specific focus on HF with preserved ejection fraction (HFpEF).
- To evaluate sPRR as a potential diagnostic indicator for HF subtypes.
Main Methods:
- Conducted a meta-analysis of existing studies on plasma sPRR levels in HF patients.
- Enrolled a new observational cohort, predominantly comprising HFpEF patients (87.8%).
- Analyzed correlations between plasma sPRR levels and clinical parameters including age, cardiac biomarkers, renal function, and hemodynamic factors.
Main Results:
- Meta-analysis revealed significantly elevated plasma sPRR levels in HF patients, with considerable statistical heterogeneity.
- The observational study found significantly higher plasma sPRR levels in HF patients compared to non-HF controls (17.4 ± 9.8 vs. 10.4 ± 3.4 ng/ml, p < 0.001).
- Plasma sPRR levels positively correlated with age, B-type natriuretic peptide, creatine, urea nitrogen, plasma renin activity, angiotensin II, and left atrial diameter, and negatively correlated with estimated glomerular filtration rate.
- sPRR demonstrated comparable diagnostic value across all HF subtypes (AUC ≥ 0.749), with average levels ≥ 16.1 ± 7.2 ng/ml indicating HF.
Conclusions:
- Plasma sPRR levels are significantly elevated in patients with heart failure (HF).
- Elevated sPRR is a potential underlying indicator for HF, applicable across different HF subtypes.
- sPRR shows promise as a diagnostic biomarker for HF, including HF with preserved ejection fraction (HFpEF).
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