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Trends in the survival of very preterm infants between 2011 and 2020 in France

Victoria Butler1,2, Luc Gaulard3, Victor Sartorius3,4

  • 1Centre for Research in Epidemiology and Statistics Obstetrical Perinatal and Pediatric Epidemiology Research Team, Paris, Île-de-France, France victoria.butler@aphp.fr.

Archives of Disease in Childhood. Fetal and Neonatal Edition
|December 27, 2024
PubMed

Insights

Survival rates for very preterm infants (less than 32 weeks gestational age) improved significantly in France between 2011 and 2020, especially for those born at 23 and 24 weeks. These findings highlight advancements in neonatal care for extremely premature babies.

Area of Science:

  • Neonatalogy
  • Perinatal Epidemiology
  • Public Health

Background:

  • The EPIPAGE-2 cohort provided initial data on very preterm infants in 2011.
  • National-level data on very preterm infant survival are crucial for assessing healthcare quality.
  • Evaluating survival trends helps identify areas for improved neonatal care.

Purpose of the Study:

  • To assess changes in survival to discharge for liveborn infants under 32 weeks gestational age in France.
  • To compare very preterm infant survival rates across 2011, 2015, and 2020.
  • To identify specific gestational age ranges showing significant survival improvements.

Main Methods:

  • Population-based cohort study utilizing EPIPAGE-2 data (2011) and national health data (2015, 2020).
  • Inclusion of all births between 22 and 31 weeks gestational age.
  • Primary outcome: survival to hospital discharge, analyzed using modified Poisson regression with adjustments for covariates.

Main Results:

  • Survival to discharge significantly increased for infants born at 23 and 24 weeks gestational age between 2011 and 2020.
  • Survival rates showed a trend of increase from 25 to 28 weeks gestational age, though not statistically significant.
  • Survival remained stable for infants between 29 and 31 weeks gestational age.
  • The proportion of live births increased for gestational ages 22-24 weeks.

Conclusions:

  • Neonatal survival rates for liveborn infants improved between 23 and 28 weeks gestational age from 2011 to 2020.
  • The most substantial improvements were observed at the earliest gestations (23-24 weeks).
  • These findings indicate progress in the management and care of very preterm infants in France.
Abstract

Keywords:
EpidemiologyIntensive Care Units, NeonatalMortalityNeonatologyResuscitation

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