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Systemic malacoplakia in a breeding pig.

H Taniyama, T Ono, T Matsui

    Journal of Comparative Pathology
    |January 1, 1985
    PubMed
    Summary
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    A rare case of systemic malacoplakia was identified in a breeding pig, affecting multiple organs. This finding highlights the potential for widespread disease presentation in veterinary pathology.

    Area of Science:

    • Veterinary Pathology
    • Comparative Pathology
    • Swine Diseases

    Background:

    • Malacoplakia is a rare inflammatory condition characterized by histiocytic accumulation and Michaelis-Gutmann bodies.
    • While documented in humans and some animal species, systemic malacoplakia in pigs is exceptionally uncommon.
    • Disseminated lesions in multiple organs suggest a significant pathological process.

    Purpose of the Study:

    • To document and characterize a unique case of systemic malacoplakia in an adult breeding pig.
    • To compare the histopathological findings with human and animal cases of malacoplakia.
    • To investigate the potential route of dissemination for the observed lesions.

    Main Methods:

    • Gross examination of thoracic and abdominal cavities revealing multiple disseminated lesions.

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  • Histopathological analysis of affected organs, including kidneys, liver, spleen, lungs, gall bladder, small intestine, and lymph nodes.
  • Microscopic evaluation for characteristic features such as histiocytic cells, giant cells, inflammatory infiltrate, and Michaelis-Gutmann bodies.

    • Main Results:

    • Multiple disseminated lesions were observed across various organs in the pig.
    • Histopathology confirmed the presence of malacoplakia, with characteristic Michaelis-Gutmann bodies.
    • The widespread distribution of lesions, particularly in perivascular areas, suggested haematogenous spread.
    • The case presented as systemic malacoplakia, a novel finding in a breeding pig.

    Conclusions:

    • The case represents systemic malacoplakia in a breeding pig, a unique and widespread presentation.
    • Histological findings were consistent with malacoplakia, supporting its occurrence in swine.
    • Haematogenous dissemination is a likely mechanism for the widespread organ involvement observed in this case.