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Washed microbiota transplantation stopped recurrent sepsis in a patient with myelofibrosis: a case report
Yingqi Yang1, Luyao Wang1, Tianchi Zhuang2
1The Second School of Clinical Medicine, Nanjing Medical University, Nanjing, 211166, China.
Background:
Sepsis represents the most prevalent infectious complication and the primary cause of mortality in myeloproliferative neoplasms (MPN). The risk of sepsis and the difficulty of treatment are significantly increased in MPN patients due to the need for immunomodulators and antibiotics.
Case Presentation:
On June 9, 2023, a 69-year-old male was admitted to the hospital. Following a battery of tests, the diagnosis of sepsis due to Escherichia coli was ultimately established. The patient was administered amoxicillin clavulanate potassium intravenously. In light of the patient's recurrent sepsis and the likelihood that the source of infection is the intestinal tract, we advised that the patient undergo washed microbiota transplantation (WMT) via a colonic transendoscopic enteral tube (TET).
Conclusions:
WMT as the new method of fecal microbiota transplantation (FMT) successfully cured the recurrent sepsis in this case, indicating the novel option for challenging the refractory or serious infections.
Insights
Washed microbiota transplantation (WMT) successfully treated recurrent Escherichia coli sepsis in a myeloproliferative neoplasm patient. This novel fecal microbiota transplantation (FMT) method offers a new option for refractory infections.
Area of Science:
- Hematology
- Gastroenterology
- Infectious Diseases
Background:
- Sepsis is a major cause of mortality in myeloproliferative neoplasms (MPN).
- MPN patients face increased sepsis risk and treatment challenges due to immunomodulators and antibiotics.
- Recurrent infections complicate management in MPN patients.
Purpose of the Study:
- To present a case of recurrent sepsis in an MPN patient.
- To evaluate the efficacy of washed microbiota transplantation (WMT) as a treatment for refractory sepsis.
Main Methods:
- A 69-year-old male with MPN diagnosed with Escherichia coli sepsis.
- Intravenous amoxicillin clavulanate potassium treatment administered.
- Washed microbiota transplantation (WMT) via colonic transendoscopic enteral tube (TET) performed due to recurrent sepsis likely originating from the intestinal tract.
Main Results:
- The patient experienced recurrent sepsis despite standard antibiotic treatment.
- Washed microbiota transplantation (WMT) was successfully performed.
- The WMT procedure led to the resolution of recurrent sepsis.
Conclusions:
- Washed microbiota transplantation (WMT) is a novel and effective method for treating refractory sepsis.
- WMT, a variation of fecal microbiota transplantation (FMT), offers a promising therapeutic option for challenging infections in immunocompromised patients.
