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Osteoarthritis: An integrative overview from pathogenesis to management
1Universiti Kebangsaan Malaysia, 43600 Bangi, Faculty of Medicine, Department of Pharmacology, 56000 Cheras, Kuala Lumpur, Malaysia.
The Malaysian Journal of Pathology
|December 28, 2024
Summary
Osteoarthritis (OA) management involves understanding its complex causes and employing diverse treatments. Early detection and emerging therapies like regenerative medicine offer new hope for patients with this degenerative joint disease.
Area of Science:
- Orthopedics and Rheumatology
- Degenerative Joint Disease Research
Background:
- Osteoarthritis (OA) is a widespread degenerative joint disease causing cartilage and bone breakdown.
- Millions globally are affected by OA, necessitating comprehensive understanding and management strategies.
Purpose of the Study:
- To provide an overview of osteoarthritis's complex etiology, integrating biochemical, mechanical, and genetic factors.
- To emphasize a multifaceted management approach for osteoarthritis, including non-pharmacological, pharmacological, and surgical treatments.
- To explore emerging regenerative medicine and personalized treatment potentials for osteoarthritis.
Main Methods:
- Literature review synthesizing current knowledge on osteoarthritis etiology and management.
- Analysis of non-pharmacological (physical therapy, lifestyle), pharmacological (NSAIDs, disease-modifying drugs), and surgical interventions.
- Exploration of advanced diagnostics and regenerative medicine in osteoarthritis care.
Main Results:
- Osteoarthritis etiology is multifactorial, involving biochemical, mechanical, and genetic influences.
- Comprehensive management includes conservative measures, pharmacotherapy, and surgery for advanced stages.
- Regenerative medicine and personalized treatments show promise for future osteoarthritis management.
Conclusions:
- Effective osteoarthritis management requires a multifaceted approach addressing its complex causes.
- Early detection through advanced diagnostics is key for timely and effective interventions.
- Emerging therapies like regenerative medicine hold significant potential to revolutionize osteoarthritis treatment.
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