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Surgical indications for pleurectomy/decortication in pleural mesothelioma based on the newly revised 9th edition of the tumour-node-metastasis classification

  • 0Second Department of Surgery, University of Occupational and Environmental Health, Japan, Yahatanishi-ku, Kitakyushu, Japan.
Interdisciplinary Cardiovascular and Thoracic Surgery +

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December 28, 2024

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December 28, 2024

View abstract on PubMed

Summary

This summary is machine-generated.

Surgery for pleural mesothelioma (PM) shows survival benefits in selected patients. The 9th edition TNM classification improves surgical candidate selection and patient outcomes for PM.

Area Of Science

  • Oncology
  • Thoracic Surgery
  • Cancer Staging

Background

  • Real-world data suggest surgical benefits for pleural mesothelioma (PM), contrasting with some trial results.
  • The 9th edition of the tumour-node-metastasis (TNM) classification includes a new pleural thickness indicator.

Purpose Of The Study

  • To evaluate the efficacy of curative surgery for PM.
  • To assess the prognostic value of the 9th edition TNM classification in PM patients undergoing surgery.

Main Methods

  • Retrospective analysis of 62 PM patients who underwent pleurectomy/decortication (2012-2022).
  • Assessment of patient characteristics, complications, and treatment outcomes.
  • Analysis of outcomes based on the 9th edition TNM classification.

Main Results

  • Median overall survival (OS) was 37.3 months; median relapse-free survival (RFS) was 15.5 months.
  • Epithelioid subtype and pStage IA showed significantly better outcomes (OS: 61.6 months, RFS: 26.0 months).
  • The 9th edition TNM classification demonstrated stronger prognostic correlation than the 8th edition for both OS and RFS.

Conclusions

  • Surgical intervention is vital for PM, especially for epithelioid histology and early stages.
  • The 9th edition TNM classification enhances precision in selecting surgical candidates for PM.
  • This revised classification may lead to improved patient outcomes in PM treatment.

Keywords:

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