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Updated: Jun 4, 2025
Quantification of the Immunosuppressant Tacrolimus on Dried Blood Spots Using LC-MS/MS
Published on: November 8, 2015
Tacrolimus-induced thrombotic microangiopathy (TMA) after heart and lung transplantation successfully treated with
Zein Kattih1, Aldo Iacono2, Christina Saikus2
1Pulmonary & Critical Care, Lenox Hill Hospital, 100 E 77th St, 4East, New York, NY 10075, United States of America.
Introduction:
Tacrolimus-induced thrombotic microangiopathy (TMA) causing acute kidney injury (AKI) without systemic features is a rare entity, particularly after non-renal solid organ transplantation.
Case Report:
We describe the case of a patient with AKI after combined heart and lung transplantation. Renal biopsy revealed acute thrombotic microangiopathy which ultimately prompted initiation of eculizumab, a monoclonal antibody targeted against complement C5, with subsequent recovery in renal function.
Results/Conclusion:
This case highlights renal isolated drug-induced TMA as a rarely reported cause of AKI post heart-lung transplantation. We emphasize the importance of performing a renal biopsy in guiding management strategies.
