Related Experiment Video
Updated: Jun 4, 2025
14:27
Identification of Disease-related Spatial Covariance Patterns using Neuroimaging Data
Published on: June 26, 2013
15.6K
Progressive structural alterations associated with negative symptoms in schizophrenia: A causal structural covariance
Chao Zhou1, Rongrong Zhang2, Mubing Ding3
1Department of Geriatric Psychiatry, Affiliated Nanjing Brain Hospital, Nanjing Medical University, Nanjing, Jiangsu, China.
Progress in Neuro-Psychopharmacology & Biological Psychiatry
|December 28, 2024
Summary
Schizophrenia negative symptoms cause progressive brain changes. Deficit schizophrenia shows specific gray matter volume and structural covariance alterations linked to symptom severity.
Area of Science:
- Neuroimaging
- Psychiatry
- Brain Structure
Background:
- Schizophrenia is linked to brain structure abnormalities.
- The impact of negative symptoms on these changes is not fully understood.
Purpose of the Study:
- Investigate gray matter volume (GMV) and structural covariance in schizophrenia.
- Explore causal effects of negative symptoms on brain alterations.
Main Methods:
- Compared 81 deficit schizophrenia (DS), 101 non-deficit schizophrenia (NDS) patients, and 177 controls.
- Used voxel-based and source-based morphometry, and Granger causality analysis.
Main Results:
- Schizophrenia patients showed reduced GMV and altered structural covariance.
- DS patients had distinct GMV reductions and covariance patterns compared to NDS.
- Negative symptom severity correlated with specific brain volume changes.
Conclusions:
- Identified unique structural covariance patterns in DS.
- Provided evidence for negative symptoms driving progressive brain abnormalities in schizophrenia.
Keywords:
Causal structural covariance networkGranger causality analysisNegative symptomsSchizophreniaMore Related Videos
Related Concept Videos
01:30Negative and Cognitive Symptoms of Schizophrenia
43
Negative symptoms of schizophrenia indicate a reduction or absence of typical behaviors and emotional responses found in healthy individuals, while positive symptoms reflect an excess or distortion of normal functioning.
Negative Symptoms
Negative symptoms of schizophrenia manifest as deficits in normal emotional and behavioral functioning, profoundly impacting daily life. Individuals with schizophrenia often display a flat affect, characterized by a near-total absence of emotional expression,...
Negative Symptoms
Negative symptoms of schizophrenia manifest as deficits in normal emotional and behavioral functioning, profoundly impacting daily life. Individuals with schizophrenia often display a flat affect, characterized by a near-total absence of emotional expression,...
43
01:29Biological Causes of Schizophrenia
44
Schizophrenia, a severe psychiatric disorder, arises from a complex interplay of biological factors, including genetic predisposition, structural brain abnormalities, neurotransmitter dysregulation, and developmental irregularities. These factors collectively contribute to the onset and progression of the disorder, which typically manifests in late adolescence or early adulthood.
Genetic Factors in Schizophrenia
The genetic basis of schizophrenia is strongly supported by family and twin...
Genetic Factors in Schizophrenia
The genetic basis of schizophrenia is strongly supported by family and twin...
44
01:30Positive Symptoms of Schizophrenia: Hallucinations and Delusions
61
Schizophrenia is a complex mental health disorder that can manifest with various positive symptoms, including thought, movement, and behavior disorders. These symptoms significantly disrupt cognitive and motor functions, leading to profound effects on an individual's ability to engage with the world.
Thought Disorders
Disorganized and unusual thought processes mark thought disorders in schizophrenia. One key feature is disorganized speech, where an individual's conversation includes...
Thought Disorders
Disorganized and unusual thought processes mark thought disorders in schizophrenia. One key feature is disorganized speech, where an individual's conversation includes...
61
01:29Psychological and Sociocultural Causes of Schizophrenia
59
Schizophrenia, a complex psychiatric disorder, has been historically misunderstood. Early psychological theories attributed its origins to childhood trauma and unresponsive parenting. However, contemporary research largely rejects these notions, favoring the vulnerability-stress hypothesis. This model proposes that individuals with a genetic predisposition to schizophrenia may develop the disorder following exposure to significant environmental stressors. Notably, studies on high-risk...
59
01:26Positive Symptoms Schizophrenia: Hallucinations and Delusions
48
Schizophrenia is a complex psychiatric disorder characterized by a range of symptoms that significantly impact cognition, behavior, and emotional regulation. Among these, the positive symptoms stand out as they involve the addition or exaggeration of normal mental functions, deviating markedly from typical behavior and perception. Hallucinations and delusions are prominent positive symptoms, each profoundly affecting the individual's experience of reality.
Hallucinations
Hallucinations in...
Hallucinations
Hallucinations in...
48
01:17Schizophrenia
68
Schizophrenia, a term introduced by Swiss psychiatrist Eugen Bleuler in 1911, describes a severe psychological disorder marked by profound disruptions in attention, thought processes, language, emotion, and interpersonal relationships. The core feature of schizophrenia is psychosis — a state characterized by a fundamental detachment from reality. This disconnection manifests through distorted logic, impaired perception, and atypical behavior, severely affecting the lives of those...
68