Related Experiment Video
Updated: May 5, 2026
11:30
Brain Imaging Investigation of the Neural Correlates of Emotional Autobiographical Recollection
Published on: August 26, 2011
9.8K
Disrupted brain networks underlying high-fidelity memory retrieval in subjective cognitive decline: A task-based fMRI
Wei Tang1,2, Qinghe Zeng1,2, Kaiqi Xie1,2
1Center on Aging Psychology, CAS Key Laboratory of Mental Health, Institute of Psychology, Chinese Academy of Sciences, Beijing, China.
Alzheimer'S & Dementia : the Journal of the Alzheimer'S Association
|December 28, 2024
Summary
Older adults with subjective cognitive decline (SCD) show objective memory retrieval deficits. Brain imaging reveals impaired hippocampus-CN connectivity, partly due to the angular gyrus, impacting memory accuracy.
Area of Science:
- Neuroscience
- Cognitive Science
- Medical Imaging
Background:
- Subjective cognitive decline (SCD) is associated with memory complaints and brain region disruptions.
- Previous studies used molecular imaging and resting-state fMRI, but the interaction of brain regions in SCD remains unclear.
Purpose of the Study:
- To investigate the neural mechanisms underlying memory deficits in SCD using task-based fMRI.
- To examine the functional connectivity (FC) between brain regions during memory retrieval in individuals with SCD.
Main Methods:
- Utilized the Mnemonic Similarity Task to assess high-fidelity retrieval.
- Employed MRI to measure group differences in brain activation and FC (generalized psychophysiological interaction) between SCD individuals and controls.
Main Results:
- Individuals with SCD exhibited worse high-fidelity retrieval, linked to hippocampal hypoactivation and control network (CN) hyperactivation.
- Reduced FC between the hippocampus and CN was observed in SCD, with the angular gyrus (AG) partially mediating this disconnection.
Conclusions:
- Confirmed objective high-fidelity retrieval deficits in older adults with SCD.
- Highlighted the role of the AG's failure to integrate neural information, contributing to memory impairments.
- Findings underscore the importance of examining disruptions in cognitive processes and neural integration in SCD.
Related Concept Videos
01:26Higher Mental Functions of Brain: Learning and Memory
2.2K
Memory is one of the most vital higher mental functions of the brain. Memory is closely related to learning because it enables us to retain information and experiences from our past to use them in our present life. It also helps us to remember facts, events, and skills, such as riding a bike or swimming. There are two types of memory — declarative memory, which involves memorizing facts or events, and procedural memory, which enables us to remember how to do something like writing or...
2.2K
01:14Role of Cerebellum and Prefrontal Cortex in Memory
1.5K
The cerebellum, while traditionally associated with motor control, also plays a crucial role in memory, particularly in procedural memory, which involves learning motor tasks that become automatic through repetition. For example, studies have shown that when the cerebellum is damaged, individuals or animals lose the ability to learn conditioned motor responses, such as the conditioned eye-blink response in classical conditioning experiments with rabbits. This study demonstrates the...
1.5K
01:13Amnesia
958
Amnesia is a condition marked by long-term memory loss, which impairs the ability to recall past events or create new memories.
The severity and duration of memory loss vary depending on the type and underlying cause. Amnesia is classified into two main types: retrograde and anterograde.
Retrograde amnesia is marked by the loss of memories formed before the onset of the condition. Patients may recall distant past events but often forget those occurring shortly before the incident.
Anterograde...
The severity and duration of memory loss vary depending on the type and underlying cause. Amnesia is classified into two main types: retrograde and anterograde.
Retrograde amnesia is marked by the loss of memories formed before the onset of the condition. Patients may recall distant past events but often forget those occurring shortly before the incident.
Anterograde...
958