Related Experiment Video
Updated: Jun 4, 2025
12:24
A Three-Dimensional Spheroid Model to Investigate the Tumor-Stromal Interaction in Hepatocellular Carcinoma
Published on: September 30, 2021
5.1K
[Liver Cirrhosis: ancient disease, new challenge]
Adrià Juanola1, Elisa Pose1, Pere Ginès2
1Servicio de Hepatología, Hospital Clínic de Barcelona, Barcelona, España; Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Catalunya, España; Centro de Investigación Biomédica en Red Enfermedades Hepáticas y Digestivas (CIBEREHD), Madrid, España.
Medicina Clinica
|December 28, 2024
Summary
Liver cirrhosis, a major cause of death, stems from alcohol and metabolic liver disease. Eliminating the cause can reverse complications, improving patient outcomes.
Area of Science:
- Hepatology
- Gastroenterology
- Internal Medicine
Background:
- Liver cirrhosis is a significant global health issue contributing to morbidity and mortality.
- Key etiological factors include excessive alcohol consumption and metabolic-associated steatotic liver disease.
- Cirrhosis presents in compensated and decompensated phases, distinguished by the presence of complications.
Purpose of the Study:
- To provide an updated review of liver cirrhosis epidemiology and causes.
- To summarize clinical features and treatment of cirrhosis complications.
- To outline future research directions in liver cirrhosis.
Main Methods:
- Literature review of epidemiological data.
- Synthesis of current knowledge on cirrhosis etiology and pathogenesis.
- Overview of established and emerging therapeutic strategies.
- Analysis of clinical manifestations and management of complications.
Main Results:
- Excessive alcohol and metabolic-associated steatotic liver disease are primary drivers of cirrhosis in the region.
- Management focuses on controlling complications like ascites, encephalopathy, infections, and hemorrhage, or liver transplantation.
- Eliminating the etiological factor can lead to disease recompensation, resolving complications.
Conclusions:
- Understanding cirrhosis epidemiology and etiology is crucial for effective management.
- Targeting etiological factors offers a pathway to disease recompensation.
- Further research is needed to advance treatment and prevention strategies for liver cirrhosis.
Related Concept Videos
01:26Diseases of the Liver and Gallbladder
450
Liver and gallbladder diseases are a significant health concern, with prominent conditions including cirrhosis, hepatitis, non-alcoholic fatty liver disease (NAFLD), and gallstones. Jaundice is a common manifestation of liver and biliary disease.
Cirrhosis is characterized by the scarring of hepatic lobules in the liver, which are replaced by fibrous tissue, affecting the liver's normal functioning. NAFLD, on the other hand, is caused by an excessive build-up of fat in the liver, not...
Cirrhosis is characterized by the scarring of hepatic lobules in the liver, which are replaced by fibrous tissue, affecting the liver's normal functioning. NAFLD, on the other hand, is caused by an excessive build-up of fat in the liver, not...
450
01:24Liver Regeneration
3.2K
The liver is an important organ in vertebrates that plays an essential role in metabolism. It is also responsible for storing and redistributing nutrients such as carbohydrates, fats, and vitamins in the body. Additionally, the liver releases bile salts which are critical for digesting food and eliminating toxic metabolites from the body.
Cells of Liver
The liver comprises four major types of cells— hepatocytes, stellate, Kupffer, and sinusoidal endothelial cells. The hepatocytes are...
Cells of Liver
The liver comprises four major types of cells— hepatocytes, stellate, Kupffer, and sinusoidal endothelial cells. The hepatocytes are...
3.2K
01:24Chronic Pancreatitis I: Introduction
71
The pancreas, an elongated and flat gland situated behind the stomach, serves a vital function in digesting food and managing blood sugar levels.
Pancreatitis is the inflammation of the pancreas, which occurs when the immune system becomes active and causes swelling, pain, and disruptions in organ function. Pancreatitis can manifest as either an acute or chronic condition.
Acute pancreatitis arises suddenly and lasts for a brief duration, while chronic pancreatitis is a long-term affliction...
Pancreatitis is the inflammation of the pancreas, which occurs when the immune system becomes active and causes swelling, pain, and disruptions in organ function. Pancreatitis can manifest as either an acute or chronic condition.
Acute pancreatitis arises suddenly and lasts for a brief duration, while chronic pancreatitis is a long-term affliction...
71
01:24Esophageal Varices-I: Introduction
72
Esophageal varices are dilated, tortuous veins which are found mainly in the submucosa of the lower esophagus but which may also appear higher up or extend into the stomach. They develop due to increased pressure in the portal venous system, often as a result of liver cirrhosis. This condition scars and damages the liver, impeding normal blood flow through the portal vein. To compensate, blood seeks alternative pathways, forming fragile new vessels (varices) in the esophagus and stomach. These...
72
01:17Chronic Bowel Disorders: Introduction
386
Chronic bowel diseases are a group of long-term conditions affecting the digestive tract, characterized by inflammation and damage to the gut lining. These conditions primarily include irritable bowel syndrome and inflammatory bowel disease.
Irritable Bowel Syndrome (IBS) is a common disorder affecting the gastrointestinal tract. The distinctive feature is recurrent abdominal pain associated with altered bowel movements, manifesting as constipation, diarrhea, or fluctuating between both. The...
Irritable Bowel Syndrome (IBS) is a common disorder affecting the gastrointestinal tract. The distinctive feature is recurrent abdominal pain associated with altered bowel movements, manifesting as constipation, diarrhea, or fluctuating between both. The...
386