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Monocytes to Apolipoprotein A1 ratio is associated with metabolic dysfunction-associated fatty liver disease in type

Wei Wang1, Lian Huang1, Xiu Ping Qiu1

  • 1Longyan First Affiliated Hospital of Fujian Medical University, Longyan, 364000, Fujian, China.

Scientific Reports
|December 29, 2024
PubMed

Insights

The monocyte-to-Apolipoprotein A1 ratio (MAR) is a strong predictor of metabolic dysfunction-associated fatty liver disease (MASLD) in type 2 diabetes patients. MAR shows higher diagnostic accuracy than MHR for MASLD screening.

Area of Science:

  • Biomarkers
  • Hepatology
  • Metabolic Syndrome

Background:

  • Metabolic dysfunction-associated fatty liver disease (MASLD) is a growing health concern, particularly in individuals with type 2 diabetes mellitus (T2DM).
  • Identifying reliable biomarkers for early detection and risk assessment of MASLD is crucial for effective management.

Purpose of the Study:

  • To investigate the association between the monocyte-to-Apolipoprotein A1 ratio (MAR) and the risk of MASLD in a T2DM cohort.
  • To compare the diagnostic efficacy of MAR with the monocyte to high-density lipoprotein ratio (MHR) for MASLD detection.

Main Methods:

  • Binomial logistic regression and restricted cubic splines (RCS) were employed to analyze the relationship between MAR and MASLD.
  • Receiver operating characteristic (ROC) curve analysis was used to compare the diagnostic accuracy of MAR and MHR.

Main Results:

  • The monocyte-to-Apolipoprotein A1 ratio (MAR) was identified as an independent predictor of MASLD, even after adjusting for confounding factors (OR 1.58, P < 0.001).
  • RCS analysis revealed a nonlinear positive association between MAR and MASLD risk (P < 0.001).
  • MAR demonstrated superior diagnostic accuracy (AUC: 0.772) compared to MHR (AUC: 0.722) for identifying MASLD (P < 0.001).

Conclusions:

  • The monocyte-to-Apolipoprotein A1 ratio (MAR) is a promising inflammatory biomarker for MASLD.
  • MAR shows potential as a valuable screening tool for MASLD management in T2DM patients.
Keywords:
Inflammatory markerMetabolic dysfunction-associated fatty liver diseaseMonocyte to Apolipoprotein A ratioType 2 diabetes mellitus

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