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Anaphylaxis is a severe, life-threatening hypersensitivity reaction mediated by Immunoglobulin E (IgE) antibodies. When IgE binds to allergens, it triggers the release of mediators– histamine, leukotrienes, and prostaglandins from mast cells and basophils. These mediators cause vasodilation, edema, and inflammation, leading to various symptoms.The primary allergens causing anaphylaxis include food items (e.g., peanuts, shellfish), drugs (e.g., penicillin, asparaginase, corticotropin,...
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Updated: May 3, 2026

A Component-resolved Diagnostic Approach for a Study on Grass Pollen Allergens in Chinese Southerners with Allergic Rhinitis and/or Asthma
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Histamine sensitivity influences reactivity to allergens.

M S Stuckey, C S Witt, L H Schmitt

    The Journal of Allergy and Clinical Immunology
    |March 1, 1985
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    Summary
    This summary is machine-generated.

    Allergen responsiveness is linked to both Immunoglobulin E (IgE) levels and histamine sensitivity. Combining these factors improves the prediction of allergic responses more accurately than using either measure alone.

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    Area of Science:

    • Allergy and Immunology
    • Dermatology

    Background:

    • Immunoglobulin E (IgE) response is crucial for allergic reactions and positive skin tests.
    • Previous studies indicate a correlation between allergen responsiveness and elevated total serum IgE concentrations.

    Purpose of the Study:

    • To investigate the contribution of histamine sensitivity to allergen responsiveness.
    • To determine if histamine sensitivity is associated with allergen responsiveness independently of IgE levels.

    Main Methods:

    • Prick testing with 14 allergens and histamine phosphate dilutions in 893 subjects.
    • Serum IgE measurement in a subset of 400 subjects.
    • Statistical analysis using three-way contingency tables.

    Main Results:

    • Confirmed a significant association between allergen responsiveness and IgE (p < 0.001).
    • Demonstrated a significant association between allergen responsiveness and histamine sensitivity (p < 0.001).
    • The association between histamine sensitivity and allergen responsiveness was independent of IgE levels.

    Conclusions:

    • Both IgE levels and histamine sensitivity are independently associated with allergen responsiveness.
    • The combined assessment of IgE and histamine sensitivity offers a more accurate prediction of allergen responsiveness.