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Related Experiment Videos

Subcutaneous blood flow in psoriasis.

P Klemp

    The Journal of Investigative Dermatology
    |March 1, 1985
    PubMed
    Summary
    This summary is machine-generated.

    This study found increased subcutaneous blood flow (SBF) in lesional skin of psoriasis vulgaris patients. This suggests altered microcirculation in psoriatic lesions, potentially linked to increased heat loss.

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    Area of Science:

    • Dermatology
    • Human Physiology
    • Medical Imaging

    Background:

    • Psoriasis vulgaris is a chronic inflammatory skin condition.
    • Altered microcirculation is suspected in psoriatic lesions.
    • Subcutaneous blood flow (SBF) is a key indicator of tissue perfusion.

    Purpose of the Study:

    • To investigate subcutaneous blood flow (SBF) in lesional skin (LS) versus nonlesional skin (NLS) of psoriasis vulgaris patients.
    • To compare SBF in psoriatic patients with healthy controls.
    • To determine if differences in washout rates reflect true SBF or tissue partition coefficients.

    Main Methods:

    • Used 133Xe washout technique to measure disappearance rates from subcutaneous adipose tissue in the crus.
    • Employed a double isotope washout method (133Xe and [131I]antipyrine) to determine tissue-to-blood partition coefficients (lambda).

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  • Performed simultaneous measurements in lesional and nonlesional skin areas of 10 psoriasis patients and in 10 healthy subjects.

    • Main Results:

    • Subcutaneous washout rate constants were significantly higher in LS compared to NLS and healthy controls.
    • Tissue-to-blood partition coefficients (lambda) for 133Xe did not differ significantly between LS, NLS, and normal tissue.
    • Calculated SBF was significantly higher in LS (3.57 ml/100 g/min) compared to NLS (2.94 ml/100 g/min), with no significant difference between NLS and controls.

    Conclusions:

    • Psoriasis vulgaris is associated with significantly increased subcutaneous blood flow in lesional skin.
    • The increased washout rates in LS are primarily due to elevated SBF, not altered tissue partition coefficients.
    • Increased SBF in psoriatic lesions may be a compensatory response to increased heat loss.