Diffusion time effects over the adult lifespan indicates persistent zone-specific microstructural alterations in the
Xiao Ma1, Peter Seres2, Adam Kinnaird3
1Department of Biomedical Engineering, University of Alberta, Edmonton, Alberta, Canada.
Magnetic Resonance in Medicine
|December 30, 2024
Summary
Aging prostates show microstructural changes with cell size increasing over time, particularly in the peripheral zone. This diffusion MRI study provides age-related data for future prostate cancer research.
Area of Science:
- Radiology
- Biomedical Engineering
- Gerontology
Background:
- Prostate microstructure changes with age.
- Diffusion MRI can detect these changes.
- Establishing normative data is crucial for prostate cancer studies.
Purpose of the Study:
- Investigate age-related prostate microstructural changes using diffusion MRI.
- Compare the effects of varying diffusion times (oscillating gradient spin echo, pulsed gradient spin echo, pulsed gradient stimulated echo).
- Provide an age-related benchmark for future prostate cancer research.
Main Methods:
- Diffusion MRI scans (OGSE, PGSE, PGSTE) of 70 male volunteers (19-69 years).
- Measurement of volume and mean diffusivity (MD) in peripheral (PZ) and transition zones (TZ).
- Analysis of MD and diffusion time effects (∆MD) versus age.
Main Results:
- Prostate zones showed quadratic age trajectories for MD, decreasing then increasing with age.
- Long diffusion time (PGSTE) MD was significantly lower, especially in PZ.
- Age-dependent increases in MD difference (∆MD) were observed, more pronounced in PZ.
Conclusions:
- Diffusion time-dependent changes indicate age-related microstructural alterations, suggesting larger cell dimensions in the aging prostate, particularly the PZ.
- This normative data serves as a reference for age-adjusted prostate cancer studies.
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