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Semaglutide-Associated Gastric Pneumatosis
Andrew M Turunen1, Reilly A Coombs1,2, Sushil Kumar Garg2
1School of Medicine, Medical College of Wisconsin-Central Wisconsin, Wausau, WI.
ACG Case Reports Journal
|December 30, 2024
Summary
Semaglutide, used for diabetes and weight loss, can cause gastrointestinal issues. A rare case of gastric pneumatosis linked to semaglutide use was observed and resolved upon drug discontinuation.
Area of Science:
- Endocrinology
- Gastroenterology
- Pharmacology
Background:
- Semaglutide, a GLP-1 receptor agonist, is widely prescribed for Type 2 diabetes and obesity management.
- Gastrointestinal adverse effects, including delayed gastric emptying, are common with semaglutide therapy.
- Gastric pneumatosis has not been previously reported in association with semaglutide use.
Observation:
- A 61-year-old male patient developed gastric pneumatosis after 9 months of semaglutide treatment.
- The patient experienced symptoms consistent with gastric pneumatosis.
- Resolution of symptoms occurred after discontinuing semaglutide.
Findings:
- This case report describes the first instance of gastric pneumatosis potentially associated with semaglutide.
- The temporal relationship suggests a possible link between semaglutide and the development of gastric pneumatosis.
- Discontinuation of semaglutide led to the resolution of the patient's symptoms.
Implications:
- Clinicians should maintain a high index of suspicion for rare gastrointestinal adverse events, such as gastric pneumatosis, in patients using semaglutide.
- Vigilance is required to identify and manage significant gastrointestinal complications associated with GLP-1 receptor agonists.
- Further research may be warranted to elucidate the potential mechanism linking semaglutide to gastric pneumatosis.
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