Mesenchymal stem cell therapy in atherosclerosis: A bibliometric and visual analysis

Area of Science:

• Biomedical Science
• Regenerative Medicine
• Cardiovascular Research

Background:

• Mesenchymal stem cells (MSCs) possess self-renewal and differentiation capabilities.
• Extensive research supports the therapeutic potential of MSCs in treating atherosclerosis (AS).

Purpose of the Study:

• To perform a bibliometric analysis of MSC therapy for AS over the last two decades.
• To identify key trends, influential publications, and future research directions in MSC-based AS therapy.

Main Methods:

• Systematic literature search of the Web of Science Core Collection (1999-2023).
• Bibliometric analysis and visualization using CiteSpace, R package 'bibliometrix', and VOSviewer.
• Analysis of 556 articles to identify publication trends, author contributions, and research hotspots.

Main Results:

• Dominant contributions from China and the United States among 52 countries/regions.
• Libby P identified as an influential author; *Int J Mol Sci* as the leading journal.
• Key research hotspots include vascular progenitor cells, inflammation, and extracellular vesicles; emerging areas are oxidative stress and extracellular vesicles.

Conclusions:

• This analysis offers valuable insights into MSC therapy for AS research.
• Identifies pivotal trends and future directions to foster innovation in the field.
• Aims to advance scientific knowledge and clinical practice for atherosclerosis treatment.