Related Experiment Video
Updated: May 7, 2025
09:55
Three-Dimensional Imaging of Aortic Tissues in Atherosclerosis
Published on: October 25, 2024
733
Association between atherosclerosis and the development of multi-organ pathologies
Siarhei A Dabravolski1, Alexey V Churov2,3, Natalia V Elizova2
1Department of Biotechnology Engineering, Braude Academic College of Engineering, Karmiel, Israel.
SAGE Open Medicine
|December 30, 2024
Summary
Atherosclerosis, a vascular disease, is linked to multiple organ dysfunctions like Alzheimer's and kidney disease. Understanding these connections may reveal new treatments for cardiovascular and related conditions.
Area of Science:
- Cardiovascular Science
- Pathophysiology
- Systemic Disease
Background:
- Atherosclerosis is a chronic inflammatory vascular disease.
- It involves lipoprotein accumulation and fibrous tissue development in vessel walls.
- Its effects extend beyond the vascular system to various organs.
Purpose of the Study:
- To review the association between atherosclerosis and other diseases.
- To discuss the reciprocal causative effects between atherosclerosis and these diseases.
- To highlight common risk factors, biomarkers, and molecular mechanisms.
Main Methods:
- Literature review of studies on atherosclerosis and associated diseases.
- Analysis of common risk factors and biomarkers.
- Examination of molecular pathways linking pathophysiology.
Main Results:
- Atherosclerosis is associated with Alzheimer's disease, stroke, pancreatic and thyroid dysfunction, and kidney diseases.
- Reciprocal causative effects exist between atherosclerosis and these conditions.
- Common risk factors and molecular mechanisms underpin these associations.
Conclusions:
- Atherosclerosis plays a significant role in multi-organ disorders.
- Understanding these links can identify novel therapeutic targets.
- This knowledge may lead to better prevention and treatment of cardiovascular and associated diseases.
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