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Association between atherosclerosis and the development of multi-organ pathologies

Siarhei A Dabravolski1, Alexey V Churov2,3, Natalia V Elizova2

  • 1Department of Biotechnology Engineering, Braude Academic College of Engineering, Karmiel, Israel.

SAGE Open Medicine
|December 30, 2024
PubMed

Insights

Atherosclerosis, a vascular disease, is linked to multiple organ dysfunctions like Alzheimer's and kidney disease. Understanding these connections may reveal new treatments for cardiovascular and related conditions.

Area of Science:

  • Cardiovascular Science
  • Pathophysiology
  • Systemic Disease

Background:

  • Atherosclerosis is a chronic inflammatory vascular disease.
  • It involves lipoprotein accumulation and fibrous tissue development in vessel walls.
  • Its effects extend beyond the vascular system to various organs.

Purpose of the Study:

  • To review the association between atherosclerosis and other diseases.
  • To discuss the reciprocal causative effects between atherosclerosis and these diseases.
  • To highlight common risk factors, biomarkers, and molecular mechanisms.

Main Methods:

  • Literature review of studies on atherosclerosis and associated diseases.
  • Analysis of common risk factors and biomarkers.
  • Examination of molecular pathways linking pathophysiology.

Main Results:

  • Atherosclerosis is associated with Alzheimer's disease, stroke, pancreatic and thyroid dysfunction, and kidney diseases.
  • Reciprocal causative effects exist between atherosclerosis and these conditions.
  • Common risk factors and molecular mechanisms underpin these associations.

Conclusions:

  • Atherosclerosis plays a significant role in multi-organ disorders.
  • Understanding these links can identify novel therapeutic targets.
  • This knowledge may lead to better prevention and treatment of cardiovascular and associated diseases.

Keywords:
Alzheimer’s diseaseAtherosclerosischronic kidney diseasekidney stonesstrokethyroid dysfunction

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