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Related Concept Videos

Diabetes Mellitus: Type 2 and Gestational01:22

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Type 2 diabetes, characterized by insulin resistance, arises when the insulin receptors on cells lose responsiveness to insulin, diminishing the cell's capacity to take up glucose, resulting in elevated blood glucose levels. To receive a diagnosis of Type 2 diabetes, a series of blood glucose tests are necessary to assess whether the blood glucose falls within normal parameters. If the result is out of the normal range, a patient may be diagnosed as prediabetic or diabetic, depending on the...
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For most patients, experiencing several weeks of polyuria, polydipsia, fatigue, and significant weight loss may indicate the presence of diabetes. Furthermore, adults displaying the phenotypic appearance of type 2 diabetes (particularly those who are obese and not initially insulin-requiring), may have islet cell autoantibodies, suggesting autoimmune-mediated β cell destruction and a diagnosis of latent autoimmune diabetes of adults (LADA). The categorization of glucose homeostasis is...
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Assessment of blood pressure in brachial artery(two-step method)01:23

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Measuring blood pressure is a fundamental skill in healthcare that aids in diagnosing and monitoring hypertension and other cardiovascular conditions. An aneroid sphygmomanometer, commonly used in clinical settings, offers a manual and precise method for blood pressure measurement. The technique for using this instrument involves specific steps that must be carefully executed to ensure accuracy. The following detailed description outlines a two-step technique for assessing blood pressure using...
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Accurate blood pressure assessment is crucial for diagnosing and managing various health conditions. To ensure the reliability of these measurements, healthcare professionals must adhere to standardized pre-procedural guidelines. These guidelines enhance patient safety and improve the overall quality of healthcare. The following steps are essential for obtaining accurate and consistent blood pressure readings, from using the appropriate tools to ensuring effective communication with the...
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Sensitivity, Specificity, and Predicted Value01:13

Sensitivity, Specificity, and Predicted Value

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In healthcare diagnostics, laboratory tests play a crucial role in identifying and diagnosing a wide range of medical conditions. However, interpreting test results is not always straightforward. An abnormal test result does not always confirm the presence of a disease, just as a normal result does not guarantee its absence. To assess the reliability of these diagnostic tools, healthcare practitioners rely on two key statistical indicators: sensitivity and specificity.
Sensitivity is the...
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Assessment of blood pressure in brachial artery(one-step method)01:15

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This procedural guide systematically measures blood pressure using an oscillometric digital sphygmomanometer, emphasizing accuracy, patient safety, and comfort.
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Related Experiment Video

Updated: May 7, 2025

Glycemic Impact on Knee Osteoarthritis Symptoms on Physical, Radiographic, and Inflammatory Markers among Individuals Aged 50 and Over with Diabetes
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External validation of Prediabetes Risk Test in Indian population for screening prediabetes.

Radhika Aditya Jadhav1, G Arun Maiya2, Shashikiran Umakanth3

  • 1PhD Scholar, Centre for Diabetic Foot Care & Research (Physiotherapy), Manipal College of Health Professions, Manipal Academy of Higher Education, Manipal, Karnataka, India.

Medical Journal, Armed Forces India
|December 30, 2024
PubMed
Summary

The Prediabetes Risk Test (PRT) shows low sensitivity (48.1%) for identifying prediabetes in Indians, but high specificity (95.5%) for ruling it out. Further research is needed to adapt the PRT for the Indian population.

Keywords:
Centre for Disease control and preventionDiabetes riskExternal validationPrediabetesPrediction model

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Area of Science:

  • Endocrinology
  • Public Health
  • Epidemiology

Background:

  • The Prediabetes Risk Test (PRT) is validated for Western populations.
  • Ethnic and biological factors influence prediabetes development.
  • Limited data exists on PRT's validity in the Indian population.

Purpose of the Study:

  • To assess the external validity of the PRT for prediabetes screening in India.
  • To determine the effectiveness of PRT in an Indian demographic.

Main Methods:

  • 522 Indian participants (18-60 years) were studied.
  • Data collected included medical history, physical activity, and anthropometrics.
  • Prediabetes diagnosis used fasting blood sugar and HbA1c; PRT validation involved sensitivity, specificity, PPV, NPV, and likelihood ratios.
  • Receiver operating characteristic (ROC) curve analysis identified optimal PRT cut-off for Indians.

Main Results:

  • PRT sensitivity was 48.1%, specificity 95.5%, positive predictive value 66.1%, and negative predictive value 90.9% in the Indian cohort.
  • ROC analysis suggested an optimal PRT cut-off of approximately 3 for Indians.

Conclusions:

  • PRT demonstrates low sensitivity, potentially limiting its utility for identifying true prediabetes cases in India.
  • High specificity suggests PRT may be effective in identifying individuals without prediabetes.
  • Modification of the PRT is recommended for improved accuracy and applicability within the Indian population.