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Thirty Days Outcomes of Limb Salvage Surgery in Pediatric Patients Treated at a Tertiary Care Hospital
Muhammad Younus Khan Durrani1, Usman Ali1, Javeria Saeed1
1Orthopaedic Surgery, Aga Khan University Hospital, Karachi, PAK.
Insights
Limb salvage surgery for pediatric bone and soft tissue sarcomas shows a 26.3% complication rate within 30 days, with surgical site infections being most common. This highlights the need for improved infection control in low- and middle-income countries (LMICs).
Area of Science:
- Pediatric Oncology
- Orthopedic Surgery
- Musculoskeletal Tumors
Background:
- Limb salvage surgery is crucial for pediatric sarcoma cure but presents post-operative challenges.
- Managing pediatric bone and soft tissue sarcomas requires specialized surgical approaches.
- Concerns about post-operative complications in limb salvage surgery persist.
Purpose of the Study:
- To evaluate the 30-day morbidity and mortality of limb salvage surgery in pediatric tumor patients.
- To identify critical knowledge gaps in pediatric sarcoma management.
- To contribute to enhancing the standard of care in low- and middle-income countries (LMICs).
Main Methods:
- A prospective cohort study was conducted on pediatric patients (≤18 years) undergoing limb salvage surgery.
- Data collected from May 2021 to October 2023 at a tertiary care hospital.
- Nineteen cases met inclusion criteria for analysis.
Main Results:
- The average patient age was 12.2 years; 63.2% had bone tumors, 36.8% soft tissue tumors.
- Osteosarcoma (36.8%) and Ewing Sarcoma (31.57%) were most common.
- 26.3% of patients experienced post-surgical complications within 30 days, including surgical site infections (21.05%) and flap necrosis (10.53%).
Conclusions:
- Limb salvage surgery in pediatric musculoskeletal tumor patients has significant early complication rates, especially in LMICs.
- Surgical site infections are a major concern, necessitating improved infection control measures.
- Nearly one-quarter of patients faced adverse events within 30 days, underscoring ongoing challenges.
Abstract:
Background Managing primary bone and soft tissue sarcomas in pediatric patients poses significant challenges, with surgical resection remaining essential for cure. While limb salvage surgery has emerged as the standard approach, concerns persist regarding post-operative complications. Our study aims to evaluate the 30-day morbidity and mortality of limb salvage surgery in pediatric tumor patients, bridging critical knowledge gaps and contributing to enhancing the standard of care in low- and middle-income countries (LMICs). Materials and methods A prospective cohort study was conducted on pediatric patients (aged 18 years or younger) who presented at a tertiary care hospital's orthopedics department and required limb salvage surgery due to various tumors from May 2021 to October 2023. Results Nineteen cases met the inclusion criteria. The average patient age was 12.2 years (SD = 4.71), with 5 (20.8%) females and 14 (79.2%) males. Bone tumors accounted for 12 (63.2%) cases, and soft tissue tumors for 7 (36.8%). Osteosarcoma was the most common tumor (36.8%), followed by Ewing Sarcoma (31.57%) and Synovial Sarcomas (15.8%). Free fibular grafts were used in 6 (31.6%) cases, and Mega prosthesis in 3 (15.8%). Overall, 26.3% of cases experienced post-surgical complications within 30 days, notably including surgical site infections (21.05%) and flap necrosis (10.53%). No significant differences in demographic and clinical variables were observed between patients with and without complications. Conclusion Our study highlights immediate post-operative outcomes and complications of limb salvage surgery in pediatric musculoskeletal tumor patients, particularly in LMIC settings. Despite advancements, early complications remain challenging, with nearly one-quarter of patients experiencing adverse events within 30 days. The prevalence of surgical site infections emphasizes the urgent need for improved infection control measures in LMICs.
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