Time course alterations of QTC interval due to hypaque 76
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Journal of Electrocardiology
|January 1, 1985
Insights
Hypaque 76 injection during left ventricular angiography caused significant QT corrected (QTc) prolongation, hypotension, and increased cardiac output in patients with normal heart structures. These effects were most pronounced within one minute post-injection.
Area of Science:
- Cardiology
- Radiology
- Pharmacology
Background:
- Left ventricular angiography is a diagnostic procedure.
- Contrast agents like Hypaque 76 are used in angiography.
- Assessing the cardiac effects of contrast agents is crucial.
Purpose of the Study:
- To evaluate the impact of Hypaque 76 on cardiac repolarization.
- To measure QT interval changes after contrast injection.
- To correlate these changes with hemodynamic parameters.
Main Methods:
- Sequential QT interval measurements were taken.
- Measurements were performed during left ventricular angiography.
- Hypaque 76 was the contrast agent used.
- Hemodynamic parameters including blood pressure and cardiac output were monitored.
Main Results:
- Significant QT corrected (QTc) prolongation was observed.
- QTc prolongation occurred within 30 seconds to one minute post-injection.
- Marked hypotension and elevated cardiac output were associated findings.
- The study included ten patients with normal ventricles and coronary arteries.
Conclusions:
- Hypaque 76 can induce transient cardiac repolarization abnormalities.
- The contrast agent significantly affects hemodynamic stability.
- Further research may be needed to understand the clinical implications of these findings.
Abstract:
Sequential measurement of QT interval during left ventricular angiography was made 30 seconds and one, three, five and ten minutes after injection of hypaque 76. The subjects were ten patients found to have normal left ventricles and coronary arteries. Significant QTC prolongation occurred in 30 seconds to one minute in association with marked hypotension and elevation of cardiac output.